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dc.contributor.authorChaiyavat Chaiyasuten_US
dc.contributor.authorBhagavathi Sundaram Sivamaruthien_US
dc.contributor.authorPeriyanaina Kesikaen_US
dc.contributor.authorSuchanat Khongtanen_US
dc.contributor.authorNanticha Khampithumen_US
dc.contributor.authorSubramanian Thangaleelaen_US
dc.contributor.authorSartjin Peerajanen_US
dc.contributor.authorAkkarach Bumrungperten_US
dc.contributor.authorKhontaros Chaiyasuten_US
dc.contributor.authorSasithorn Sirilunen_US
dc.contributor.authorPhakkharawat Sittiprapapornen_US
dc.description.abstractThe cluster of metabolic disorders includes obesity, dyslipidemia, hypertension, and glucose intolerance, increasing the risk of developing cardiovascular diseases and type 2 diabetes. Evolving proofs suggest an essential role of microbiota in human health and disease, including digestion, energy and glucose metabolism, immunomodulation, and brain function. The frequency of overweight is increasing, and the main causes for this are highly processed foods and less active lifestyles. Research is underway to unravel the probable relationship between obesity and intestinal microbiota. Here, we propose a method to understand and elucidate the synergistic function of prebiotics and probiotics in treating obesity. The biomarkers of obesity, such as cholesterol, gut permeability, oxidative stress, bacterial toxins, cytokines, and short-chain fatty acids, were analyzed in Thai obese individuals after being supplemented with a synbiotic preparation containing Lactobacillus paracasei, Bifidobacterium longum, Bifidobacterium breve, inulin, and fructooligosaccharide. The results reveal that the supplementation of synbiotics significantly altered the obesity-associated biomarkers in an appositive way. Further studies are warranted to use synbiotics as an adjuvant therapy for the management of obesity-related health issues.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectHealth Professionsen_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectSocial Sciencesen_US
dc.titleSynbiotic supplementation improves obesity index and metabolic biomarkers in thai obese adults: A randomized clinical trialen_US
article.volume10en_US Mai Rajabhat Universityen_US Fah Luang Universityen_US Universityen_US Pundit Universityen_US Mai Universityen_US Innovation Instituteen_US
Appears in Collections:CMUL: Journal Articles

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