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dc.contributor.authorYasir Naziren_US
dc.contributor.authorPichchapa Linsaenkarten_US
dc.contributor.authorChiranan Khanthamen_US
dc.contributor.authorTanakarn Chaitepen_US
dc.contributor.authorPensak Jantrawuten_US
dc.contributor.authorChuda Chittasuphoen_US
dc.contributor.authorPornchai Rachtanapunen_US
dc.contributor.authorKittisak Jantanasakulwongen_US
dc.contributor.authorYuthana Phimolsiripolen_US
dc.contributor.authorSarana Rose Sommanoen_US
dc.contributor.authorJiraporn Tocharusen_US
dc.contributor.authorSalin Mingmalairaken_US
dc.contributor.authorAnchali Wongsaen_US
dc.contributor.authorChaiwat Arjinen_US
dc.contributor.authorKorawan Sringarmen_US
dc.contributor.authorHouda Berradaen_US
dc.contributor.authorFrancisco J. Barbaen_US
dc.contributor.authorWarintorn Ruksiriwanichen_US
dc.description.abstractDictyophora indusiata or Phallus indusiatus is widely used as not only traditional medicine, functional foods, but also, skin care agents. Biological activities of the fruiting body from D. indusiata were widely reported, while the studies on the application of immature bamboo mushroom extracts were limited especially in the wound healing effect. Wound healing process composed of 4 stages including hemostasis, inflammation, proliferation, and remodelling. This study divided the egg stage of bamboo mushroom into 3 parts: peel and green mixture (PGW), core (CW), and whole mushroom (WW). Then, aqueous extracts were investigated for their nucleotide sequencing, biological compound contents, and wound healing effect. The anti-inflammatory determination via the levels of cytokine releasing from macrophages, and the collagen stimulation activity on fibroblasts by matrix metalloproteinase-2 (MMP-2) inhibitory activity were determined to serve for the wound healing process promotion in the stage 2–4 (wound inflammation, proliferation, and remodelling of the skin). All D. indusiata extracts showed good antioxidant potential, significantly anti-inflammatory activity in the decreasing of the nitric oxide (NO), interleukin-1 (IL-1), interleukin-1 (IL-6), and tumour necrosis factor-α (TNF-α) secretion from macrophage cells (p < 0.05), and the effective collagen stimulation via MMP-2 inhibition. In particular, CW extract containing high content of catechin (68.761 ± 0.010 mg/g extract) which could significantly suppress NO secretion (0.06 ± 0.02 µmol/L) better than the standard anti-inflammatory drug diclofenac (0.12 ± 0.02 µmol/L) and their MMP-2 inhibition (41.33 ± 9.44%) was comparable to L-ascorbic acid (50.65 ± 2.53%). These findings support that CW of D. indusiata could be an essential natural active ingredient for skin wound healing pharmaceutical products.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.titleHigh efficiency in vitro wound healing of dictyophora indusiata extracts via anti-inflammatory and collagen stimulating (MMP-2 inhibition) mechanismsen_US
article.title.sourcetitleJournal of Fungien_US
article.volume7en_US de Valènciaen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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