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dc.contributor.authorSasinee Hantrakoolen_US
dc.contributor.authorSirinart Kumfuen_US
dc.contributor.authorSiriporn C. Chattipakornen_US
dc.contributor.authorNipon Chattipakornen_US
dc.description.abstractAmbient air pollution has become a common problem worldwide. Exposure to pollutant particles causes many health conditions, having a particular impact on pulmonary and cardiovascular disease. Increased understanding of the pathological processes related to these conditions may facilitate the prevention of the adverse impact of air pollution on our physical health. Evidence from in vitro, in vivo, and clinical studies has consistently shown that exposure to particulate matter could induce the inflammatory responses such as IL-6, TNF-α, IL-1β, as well as enhancing the oxidative stress. These result in vascular injury, adhesion molecule release, platelet activation, and thrombin generation, ultimately leading to a prothrombotic state. In this review, evidence on the effects of particulate matter on inflammation, oxidative stress, adhesion molecules, and coagulation pathways in enhancing the risk of thrombosis is comprehensively summarized and discussed. The currently available outcomes of interventional studies at a cellular level and clinical reports are also presented and discussed.en_US
dc.subjectEnvironmental Scienceen_US
dc.titleEffects of Particulate Matter on Inflammation and Thrombosis: Past Evidence for Future Preventionen_US
article.title.sourcetitleInternational Journal of Environmental Research and Public Healthen_US
article.volume19en_US of Medicine, Chiang Mai Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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