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dc.contributor.authorAiyarin Kittilukkanaen_US
dc.contributor.authorThipjutha Phatruengdeten_US
dc.contributor.authorJannarong Intakhaden_US
dc.contributor.authorArpamas Chariyakornkulen_US
dc.contributor.authorRawiwan Wongpoomchaien_US
dc.contributor.authorChalermchai Pilapongen_US
dc.description.abstractIron-containing drugs can be considered beneficial for noninvasive magnetic resonance imaging (MRI) and induction of essential biochemical processes. Herein, we present a new type of iron-containing drug based on molecular nanoparticles of ferric-tannic complexes (FTs), which could be used to enhance noninvasive brain MRI and modulate brain clearance pathways. Once intravenously administered to healthy Wistar rats, the maximum enhancement of the T1-weighted MRI signal was observed at 0.5 h postinjection, corresponding to their maximum accumulation in the brain. After this time, FTs were rapidly cleared by the brain, which was possibly modulated by organic anion transporters present at the blood-brain barrier. This result describes the "come-and-run"concept of FTs, which could be utilized as a brain-targeting agent for various purposes. Although the "come-and-run"mechanism allows them to have a short half-life in the brain, they remain long enough to activate brain clearance pathways such as autophagy, lysosomal function, and cellular clearance. Therefore, FTs could be considered new clinically translatable pharmaceuticals for brain MRI and the prevention of brain aging and related diseases.en_US
dc.titleMolecular Nanoparticles of Ferric-Tannic Complexes Enhance Brain Magnetic Resonance Imaging and Activate Brain Clearance Pathwaysen_US
article.title.sourcetitleAnalytical Chemistryen_US of Medicine, Chiang Mai Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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