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dc.contributor.authorSarana Rose Sommanoen_US
dc.contributor.authorPiyachat Sunantaen_US
dc.contributor.authorNoppol Leksawasdien_US
dc.contributor.authorKittisak Jantanasakulwongen_US
dc.contributor.authorPornchai Rachtanapunen_US
dc.contributor.authorPhisit Seesuriyachanen_US
dc.contributor.authorYuthana Phimolsiripolen_US
dc.contributor.authorKorawan Sringarmen_US
dc.contributor.authorWarintorn Ruksiriwanichen_US
dc.contributor.authorPensak Jantrawuten_US
dc.contributor.authorChuda Chittasuphoen_US
dc.description.abstractPhytocannabinoids are isoprenylated resorcinyl polyketides produced mostly in glandular trichomes of Cannabis sativa L. These discoveries led to the identification of cannabinoid recep-tors, which modulate psychotropic and pharmacological reactions and are found primarily in the human central nervous system. As a result of the biogenetic process, aliphatic ketide phytocanna-binoids are exclusively found in the cannabis species and have a limited natural distribution, whereas phenethyl-type phytocannabinoids are present in higher plants, liverworts, and fungi. The development of cannabinomics has uncovered evidence of new sources containing various phyto-cannabinoid derivatives. Phytocannabinoids have been isolated as artifacts from their carboxylated forms (pre-cannabinoids or acidic cannabinoids) from plant sources. In this review, the overview of the phytocannabinoid biosynthesis is presented. Different non-cannabis plant sources are described either from those belonging to the angiosperm species and bryophytes, together with their metab-olomic structures. Lastly, we discuss the legal framework for the ingestion of these biological materials which currently receive the attention as a legal high.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleMass Spectrometry-Based Metabolomics of Phytocannabinoids from Non-Cannabis Plant Originsen_US
article.volume27en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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