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dc.contributor.authorWarintorn Ruksiriwanichen_US
dc.contributor.authorChiranan Khanthamen_US
dc.contributor.authorAnurak Muangsanguanen_US
dc.contributor.authorChuda Chittasuphoen_US
dc.contributor.authorPornchai Rachtanapunen_US
dc.contributor.authorKittisak Jantanasakulwongen_US
dc.contributor.authorYuthana Phimolsiripolen_US
dc.contributor.authorSarana Rose Sommanoen_US
dc.contributor.authorKorawan Sringarmen_US
dc.contributor.authorEmilia Ferreren_US
dc.contributor.authorFrancisco J. Barbaen_US
dc.description.abstractIn Thai folklore wisdom, shallot (Allium ascalonicum L.) was applied as a traditional herbal medicine for hair growth promotion with no scientific evidence. Androgenetic alopecia (AGA) is a progressive hair loss caused by multiple factors, including androgen hormones, inflammation, and oxidative stress. Conventional medicines (finasteride, dutasteride, corticosteroids, and minoxidil) have been used with limited therapeutic efficacy and unpleasant side effects. In this study, we aimed to give the first estimation of bioactive compounds in shallot extract and evaluate the hair growth‐promoting activities regarding anti‐inflammatory and gene expression modulation involving androgen, Wnt/β‐catenin, sonic hedgehog, and angiogenesis pathways. The results reveal that phenolic compounds (quercetin, rosmarinic, and p‐coumaric acids) are the major constituents of the methanolic shallot extract. Compared with the lipopolysaccharide‐stimulated control group (2.68 ± 0.13 μM), nitric oxide production was remarkably diminished by shallot extract (0.55 ± 0.06 μM). Shallot extract improves hair growth promotion activity, as reflected by the downregulation of the androgen gene expression (SRD5A1 and SRD5A2) and the upregulation of the genes associated with Wnt/β‐catenin (CTNNB1), sonic hedgehog (SHH, SMO, and GIL1), and angiogenesis (VEGF) pathways. These findings disclose the new insights of shallot extract on hair growth promotions. Shallot extract could be further developed as nutraceutical, nutricosmetic, and cosmeceutical preparations for AGA treatment.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectEnvironmental Scienceen_US
dc.titlePhytochemical Constitution, Anti‐Inflammation, Anti‐Androgen, and Hair Growth‐Promoting Potential of Shallot (Allium ascalonicum L.) Extracten_US
article.volume11en_US de Valènciaen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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