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Title: | Exposure to organophosphates in association with the development of insulin resistance: Evidence from in vitro, in vivo, and clinical studies |
Authors: | Mathuramat Seesen Wasana Pratchayasakul Hiranya Pintana Nipon Chattipakorn Siriporn C. Chattipakorn |
Authors: | Mathuramat Seesen Wasana Pratchayasakul Hiranya Pintana Nipon Chattipakorn Siriporn C. Chattipakorn |
Keywords: | Agricultural and Biological Sciences;Pharmacology, Toxicology and Pharmaceutics |
Issue Date: | 1-Oct-2022 |
Abstract: | Insulin resistance is an underlying condition prior to the development of several diseases, including type 2 diabetes, cardiovascular diseases, cognitive impairment, and cerebrovascular complications. Organophosphates (OPs) are one of several factors thought to induce insulin resistance. Previous studies showed that the exposure to OPs pesticides induced insulin resistance through the impairment of hepatic glucose metabolism, pancreatic damage, and disruption of insulin signaling of both adipose tissues and skeletal muscles. Several studies reported possible mechanisms associated with OPs-induced insulin resistance in different models in in vivo studies including those in adult animals, obese animals, and offspring models, as well as in clinical studies. In addition, pharmacological interventions in OPs-induced insulin resistance have been previously investigated. This review aims to summarize and discuss all the evidence concerning OPs-induced insulin resistance in different models including in vitro, in vivo and clinical studies. The interventions of OPs-induced insulin resistance are also discussed. Any contradictory findings also considered. The information from this review will provide insight for possible therapeutic approaches to OPs-induced insulin resistance in the future. |
URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137306590&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/74261 |
ISSN: | 18736351 02786915 |
Appears in Collections: | CMUL: Journal Articles |
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