Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/74261
Title: Exposure to organophosphates in association with the development of insulin resistance: Evidence from in vitro, in vivo, and clinical studies
Authors: Mathuramat Seesen
Wasana Pratchayasakul
Hiranya Pintana
Nipon Chattipakorn
Siriporn C. Chattipakorn
Authors: Mathuramat Seesen
Wasana Pratchayasakul
Hiranya Pintana
Nipon Chattipakorn
Siriporn C. Chattipakorn
Keywords: Agricultural and Biological Sciences;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Oct-2022
Abstract: Insulin resistance is an underlying condition prior to the development of several diseases, including type 2 diabetes, cardiovascular diseases, cognitive impairment, and cerebrovascular complications. Organophosphates (OPs) are one of several factors thought to induce insulin resistance. Previous studies showed that the exposure to OPs pesticides induced insulin resistance through the impairment of hepatic glucose metabolism, pancreatic damage, and disruption of insulin signaling of both adipose tissues and skeletal muscles. Several studies reported possible mechanisms associated with OPs-induced insulin resistance in different models in in vivo studies including those in adult animals, obese animals, and offspring models, as well as in clinical studies. In addition, pharmacological interventions in OPs-induced insulin resistance have been previously investigated. This review aims to summarize and discuss all the evidence concerning OPs-induced insulin resistance in different models including in vitro, in vivo and clinical studies. The interventions of OPs-induced insulin resistance are also discussed. Any contradictory findings also considered. The information from this review will provide insight for possible therapeutic approaches to OPs-induced insulin resistance in the future.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137306590&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/74261
ISSN: 18736351
02786915
Appears in Collections:CMUL: Journal Articles

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