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dc.contributor.authorWarintorn Ruksiriwanichen_US
dc.contributor.authorChiranan Khanthamen_US
dc.contributor.authorPichchapa Linsaenkarten_US
dc.contributor.authorTanakarn Chaitepen_US
dc.contributor.authorPensak Jantrawuten_US
dc.contributor.authorChuda Chittasuphoen_US
dc.contributor.authorPornchai Rachtanapunen_US
dc.contributor.authorKittisak Jantanasakulwongen_US
dc.contributor.authorYuthana Phimolsiripolen_US
dc.contributor.authorSarana Rose Sommanoen_US
dc.contributor.authorChaiwat Arjinen_US
dc.contributor.authorHouda Berradaen_US
dc.contributor.authorFrancisco J. Barbaen_US
dc.contributor.authorKorawan Sringarmen_US
dc.description.abstractOily skin from overactive sebaceous glands affects self-confidence and personality. There is report of an association between steroid 5-alpha reductase gene (SRD5A) expression and facial sebum production. There is no study of the effect of Asparagus racemosus Willd. root extract on the regulation of SRD5A mRNA expression and anti-sebum efficacy. This study extracted A. racemosus using the supercritical carbon dioxide fluid technique with ethanol and investigated its biological compounds and activities. The A. racemosus root extract had a high content of polyphenolic compounds, including quercetin, naringenin, and p-coumaric acid, and DPPH scavenging activity comparable to that of the standard L-ascorbic acid. A. racemosus root extract showed not only a significant reduction in SRD5A1 and SRD5A2 mRNA expression by about 45.45% and 90.86%, respectively, but also a reduction in the in vivo anti-sebum efficacy in male volunteers, with significantly superior percentage changes in facial sebum production and a reduction in the percentages of pore area after 15 and 30 days of treatment. It can be concluded that A. racemosus root extract with a high content of polyphenol compounds, great antioxidant effects, promising downregulation of SRD5A1 and SRD5A2, and predominant facial sebum reduction and pore-minimizing efficacy could be a candidate for an anti-sebum and pore-minimizing active ingredient to serve in functional cosmetic applications.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleIn Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus racemosus Willd. Root as Anti-Sebum and Pore-Minimizing Active Ingredientsen_US
article.volume27en_US de Valènciaen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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