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dc.contributor.authorEkasit Lalitsuradejen_US
dc.contributor.authorSasithorn Sirilunen_US
dc.contributor.authorPhakkharawat Sittiprapapornen_US
dc.contributor.authorBhagavathi Sundaram Sivamaruthien_US
dc.contributor.authorKomsak Pinthaen_US
dc.contributor.authorPayungsak Tantipaiboonwongen_US
dc.contributor.authorSuchanat Khongtanen_US
dc.contributor.authorPranom Fukngoenen_US
dc.contributor.authorSartjin Peerajanen_US
dc.contributor.authorChaiyavat Chaiyasuten_US
dc.description.abstractUrbanization influences our lifestyle, especially in fast-paced environments where we are more prone to stress. Stress management is considered advantageous in terms of longevity. The use of probiotics for psychological treatment has a small amount of diverse proven evidence to support this. However, studies on stress management in stressed subjects using synbiotics are still limited. The present study aimed to investigate the effects of synbiotics on stress in the Thai population. A total of 32 volunteers were enrolled and screened using a Thai Stress Test (TST) to determine their stress status. Participants were divided into the stressed and the non-stressed groups. Synbiotics preparation comprised a mixture of probiotics strains in a total concentration of 1 × 1010 CFU/day (5.0 × 109 CFU of Lactobacillus paracasei HII01 and 5.0 × 109 CFU of Bifidobacterium animalis subsp. lactis) and 10 g prebiotics (5 g galacto-oligosaccharides (GOS), and 5 g oligofructose (FOS)). All parameters were measured at baseline and after the 12th week of the study. In the stressed group, the administration of synbiotics significantly (p < 0.05) reduced the negative scale scores of TST, and tryptophan. In the non-stressed group, the synbiotics administration decreased tryptophan significantly (p < 0.05), whereas dehydroepiandrosterone sulfate (DHEA-S), tumor necrosis factor-α (TNF-α), 5-hydroxyindoleacetic acid (5-HIAA), and short-chain fatty acids (SCFAs), acetate and propionate were increased significantly (p < 0.05). In both groups, cortisol, and lipopolysaccharide (LPS) were reduced, whereas anti-inflammatory mediator interleukin-10 (IL-10) and immunoglobulin A (IgA) levels were increased. In conclusion, synbiotics administration attenuated the negative feelings via the negative scale scores of TST in stressed participants by modulating the HPA-axis, IL-10, IgA, and LPS. In comparison, synbiotics administration for participants without stress did not benefit stress status but showed remodeling SCFAs components, HPA-axis, and tryptophan catabolism.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectHealth Professionsen_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectSocial Sciencesen_US
dc.titleThe Effects of Synbiotics Administration on Stress-Related Parameters in Thai Subjects—A Preliminary Studyen_US
article.volume11en_US of Phayaoen_US Fah Luang Universityen_US Mai Universityen_US Innovation Instituteen_US of Research Administrationen_US
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