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dc.contributor.authorSukanya Dej-adisaien_US
dc.contributor.authorNasrin Basowen_US
dc.contributor.authorChatchai Wattanapiromsakulen_US
dc.contributor.authorWanlapa Nuankaewen_US
dc.contributor.authorTong Ho Kangen_US
dc.date.accessioned2021-04-23T08:50:35Z-
dc.date.available2021-04-23T08:50:35Z-
dc.date.issued2021en_US
dc.identifier.citationChiang Mai Journal of Science 48, 1 (January 2021), 27-41en_US
dc.identifier.issn2465-3845en_US
dc.identifier.urihttps://epg.science.cmu.ac.th/ejournal/dl.php?journal_id=11438en_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/72031-
dc.descriptionThe Chiang Mai Journal of Science is an international English language peer-reviewed journal which is published in open access electronic format 6 times a year in January, March, May, July, September and November by the Faculty of Science, Chiang Mai University. Manuscripts in most areas of science are welcomed except in areas such as agriculture, engineering and medical science which are outside the scope of the Journal. Currently, we focus on manuscripts in biology, chemistry, physics, materials science and environmental science. Papers in mathematics statistics and computer science are also included but should be of an applied nature rather than purely theoretical. Manuscripts describing experiments on humans or animals are required to provide proof that all experiments have been carried out according to the ethical regulations of the respective institutional and/or governmental authorities and this should be clearly stated in the manuscript itself. The Editor reserves the right to reject manuscripts that fail to do so.en_US
dc.description.abstractTyrosinase is the most important enzyme that can approach towards controlling melanin production for hyperpigmentation treatment. The 104 samples were extracted from 54 fungi which were isolated from organic soil at Sirindhorn peat swamp forest, Narathiwat province, Thailand. They were screened on tyrosinase inhibition. From the results, four samples as SPSF318BE, SPSF011BE, SPSF318CE and SPSF045BE showed the potent tyrosinase inhibitory activity with more than 50% at 20 μg/ml. Their tyrosinase inhibitions were 78.83/2.72%, 75.80/2.65%, 72.45/3.55% and 58.04/1.46%, respectively. While positive controls as the water extract of Artocarpus lakoocha wood and kojic acid could inhibit this enzyme with 94.26/0.65% and 80.18/0.84%, respectively. The most active sample was selected for further study, the fungus SPSF318 was identified by using molecular method as Aspergillus flavus. The crude extracts of A. flavus were evaluated for inhibition of cellular tyrosinase, melanin synthesis on B16F1 melanoma cells, pigmentation inhibitory effects on zebrafish, antioxidant and anti-microbial activities against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Pseudomonas aeruginosa and Escherichia coli. In addition, A. flavus has to further study of chemical constituents in order to figure out the active compound which might be the lead compound for whitening agent. Therefore, isolated soil fungi in this area could be considered as good sources of various bioactive natural products, especially, to identify new inhibitor with drug-like properties on tyrosinase enzyme activity.en_US
dc.language.isoEngen_US
dc.publisherFaculty of Science, Chiang Mai Universityen_US
dc.subjectfungal extractsen_US
dc.subjectbiological activitiesen_US
dc.subjectanti-tyrosinase activityen_US
dc.subjectAspergillus flavusen_US
dc.subjectSirindhorn Peat Swamp Foresten_US
dc.titleEffect of Isolated Soil Fungi from Sirindhorn Peat Swamp Forest Narathiwat Province, Thailand on Tyrosinase Enzyme and Melanin Contenten_US
Appears in Collections:CMUL: Journal Articles

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