Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/71710
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dc.contributor.authorSiriporn Peansukmaneeen_US
dc.contributor.authorSiriwan Tangyuenyongen_US
dc.contributor.authorSiriwan Ongchaien_US
dc.date.accessioned2021-01-27T04:05:34Z-
dc.date.available2021-01-27T04:05:34Z-
dc.date.issued2020-01-01en_US
dc.identifier.issn13036181en_US
dc.identifier.issn13000128en_US
dc.identifier.other2-s2.0-85084635691en_US
dc.identifier.other10.3906/vet-1811-66en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85084635691&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/71710-
dc.description.abstract© TÜBITAK. Black sesame seed is a potential herbal medicine for osteoarthritis treatment as it contains sesamin, which has antiinflammatory properties and has demonstrated chondroprotective effects in many species. Horses are particularly susceptible to osteoarthritis. Inflammatory mediators and matrix metalloproteinase are important factors causing cartilage degradation. This study aimed to investigate the protective potential of sesamin (0.5-2.0 μM) against interleukin (IL)-1β-induced equine cartilage explant degradation. The cartilage degradation was monitored by measuring the release of cartilage matrix molecules in culture media including sulfated-glycosaminoglycans and hyaluronan by calorimetric assay and ELISA assay, respectively. The remaining contents of collagen and uronic acid (UA) within the explant tissue were assessed by hydroxyproline assay and UA assay, respectively. Cartilage-degrading enzymes MMP-2 and MMP-3 were evaluated by gelatin zymography and ELISA assay, respectively. The results indicated that sesamin suppressed IL-1β-induced equine cartilage degradation by reducing the levels of sulfated-glycosaminoglycans and hyaluronan, and preserving the contents of UA and collagen within the explant tissues. The activity of MMP-2 and the quantity of MMP-3 were also suppressed by sesamin. The chondroprotective efficacy of sesamin was comparable to that of diacerein, an antiarthritic drug. Lactate dehydrogenase assay showed that sesamin at concentrations of up to 2 mM did not cause cytotoxicity to chondrocytes in cartilage explants. These results may lead to new options for osteoarthritis treatment in horses.en_US
dc.subjectVeterinaryen_US
dc.titleEffect of sesamin on protection of equine articular cartilage degradation in vitroen_US
dc.typeJournalen_US
article.title.sourcetitleTurkish Journal of Veterinary and Animal Sciencesen_US
article.volume44en_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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