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dc.contributor.authorNatsima Viriyaadhammaaen_US
dc.contributor.authorAroonchai Saiaien_US
dc.contributor.authorWaranya Neimkhumen_US
dc.contributor.authorWariya Nirachonkulen_US
dc.contributor.authorWantida Chaiyanaen_US
dc.contributor.authorSawitree Chiampanichayakulen_US
dc.contributor.authorSingkome Timaen_US
dc.contributor.authorToyonobu Usukien_US
dc.contributor.authorSuwit Duangmanoen_US
dc.contributor.authorSongyot Anuchapreedaen_US
dc.description.abstractCurcuma comosa belongs to the Zingiberaceae family. In this study, two natural compounds were isolated from C. comosa, and their structures were determined using nuclear magnetic resonance. The isolated compounds were identified as 7-(3,4-dihydroxyphenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene (1) and trans-1,7-diphenyl-5-hydroxy-1-heptene (2). Compound 1 showed the strongest cytotoxicity effect against HL-60 cells, while its antioxidant and anti-inflammatory properties were stronger than those of compound 2. Compound 1 proved to be a potent antioxidant, compared to ascorbic acid. Neither compounds had any effect on red blood cell haemolysis. Furthermore, compound 1 significantly decreased Wilms' tumour 1 protein expression and cell proliferation in KG-1a cells. Compound 1 decreased the WT1 protein levels in a time- and dose- dependent manner. Compound 1 suppressed cell cycle at the S phase. In conclusion, compound 1 has a promising chemotherapeutic potential against leukaemia.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleCytotoxic and Antiproliferative Effects of Diarylheptanoids Isolated from Curcuma comosa Rhizomes on Leukaemic Cellsen_US
article.title.sourcetitleMolecules (Basel, Switzerland)en_US
article.volume25en_US Chalermprakiet Universityen_US Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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