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dc.contributor.authorLindsay Wieczoreken_US
dc.contributor.authorKristina Peachmanen_US
dc.contributor.authorDaniel J. Adamsen_US
dc.contributor.authorBrittani Barrowsen_US
dc.contributor.authorSebastian Molnaren_US
dc.contributor.authorJesse Schoenen_US
dc.contributor.authorPeter Dawsonen_US
dc.contributor.authorChris Bryanten_US
dc.contributor.authorAgnès Laurence Chenineen_US
dc.contributor.authorEric Sanders-Buellen_US
dc.contributor.authorKriengkrai Srithanaviboonchaien_US
dc.contributor.authorPanita Pathipvanichen_US
dc.contributor.authorNelson L. Michaelen_US
dc.contributor.authorMerlin L. Robben_US
dc.contributor.authorSodsai Tovanabutraen_US
dc.contributor.authorMangala Raoen_US
dc.contributor.authorVictoria R. Polonisen_US
dc.description.abstract© 2020 Elsevier Inc. Despite anti-retroviral therapy (ART) interventions for HIV+ pregnant mothers, over 43,000 perinatal infections occur yearly. Understanding risk factors that lead to mother-to-child transmission (MTCT) of HIV are critical. We evaluated maternal and infant plasma binding and neutralizing antibody responses in a drug-naïve, CRF01_AE infected MTCT cohort from Thailand to determine associations with transmission risk. Env V3-specific IgG and neutralizing antibody responses were significantly higher in HIV- infants, as compared to HIV+ infants. In fact, infant plasma neutralizing antibodies significantly associated with non-transmission. Conversely, increased maternal Env V3-specific IgG and neutralizing antibody responses were significantly associated with increased transmission risk, after controlling for maternal viral load. Our results highlight the importance of evaluating both maternal and infant humoral immune responses to better understand mechanisms of protection, as selective placental antibody transport may have a role in MTCT. This study further emphasizes the complex role of Env-specific antibodies in MTCT of CRF01_AE HIV.en_US
dc.subjectImmunology and Microbiologyen_US
dc.titleEvaluation of HIV-1 neutralizing and binding antibodies in maternal-infant transmission in Thailanden_US
article.volume548en_US EMMES Corporationen_US Reed Army Institute of Researchen_US Services University of the Health Sciencesen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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