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dc.contributor.authorEhsan Ahmadifaren_US
dc.contributor.authorMahmoud A.O. Dawooden_US
dc.contributor.authorMohsen Shahriyari Moghadamen_US
dc.contributor.authorAli Hashemi Shahrestanakien_US
dc.contributor.authorHien Van Doanen_US
dc.contributor.authorAdel H. Saaden_US
dc.contributor.authorMohamed Aboubakren_US
dc.contributor.authorEhab Y. Abdelhieeen_US
dc.contributor.authorSabreen E. Fadlen_US
dc.description.abstract© 2020 This study investigated the influence of probiotic Pediococcus acidilactici MA 18/5 M on the metabolic enzyme activities and mRNA levels of growth, immunity, and antioxidative-related genes in zebrafish. Zebrafish fed with diets containing P. acidilactici MA 18/5 M at 0, 107, 108, and 109 CFU/g levels for eight weeks. The obtained results revealed that the creatine phosphokinase, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase remained unchanged in all groups (P > 0.05). Dietary P. acidilactici enhanced protease activity relative to the control group (P < 0.05). Compared with the non-treated group, lysozyme activity increased in fish fed with high and medium doses of P. acidilactici, but the mRNA level of lysozyme gene was only up-regulated in the fish received the high dose of P. acidilactici (P < 0.05). Meanwhile, gene expressions of IGF-1, TNF-α, GH-1, and catalase were increased by P. acidilactici at 107 CFU/g relative to the control group. Conversely, the expression of glutathione S-reductase (GSR) decreased in zebrafish fed with medium and high doses of P. acidilactici compared to the control group. Thus, dietary administration of P. acidilactici MA 18/5 M, especially at 107 CFU/g diet, could improve the growth, immunity, and health status of zebrafish.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.titleThe effect of Pediococcus acidilactici MA 18/5M on immune responses and mRNA levels of growth, antioxidant and immune-related genes in zebrafish (Danio rerio)en_US
article.title.sourcetitleAquaculture Reportsen_US
article.volume17en_US Universityen_US of Zabolen_US Universityen_US Universityen_US Azad University, North Tehran Branchen_US Mai Universityen_US
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