A Poly(pyrrole-3-carboxylic acid) Thin Film Modified Screen Printed Carbon Electrode as Highly Sensitive and Selective Label-free Electrochemical Immunosensing Platform

Abstract

Giving good stability and sensitivity of the low-cost electrochemical immunosensor is achieved using a conducting poly(pyrrole-3-carboxylic acid) (PP3C) film on a screen-printed carbon electrode (SPCE). The PP3C film offers high density surface carboxylic groups, on which can be covalently conjugated with capturing antibodies, and improves electrode reactivity. Our simple immunosensor exhibitessatisfactory sensitivity, selectivity, stability, reproducibility, and regenerability for the detection of human immunoglobulin G (IgG). The proposed sensitive immunosensor provides a detection limit of 0.120 ng mL-1 and a sensitivity of 3.61 μA cm-2 mL ng-1, which thus is promising for clinical applications.