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dc.contributor.authorApichaya Kapanyaen_US
dc.contributor.authorRunglawan Somsunanen_US
dc.contributor.authorRobert Molloyen_US
dc.contributor.authorSupat Jiranusornkulen_US
dc.contributor.authorWorraanong Leewattanapasuken_US
dc.contributor.authorLeena Jongpaiboonkiten_US
dc.contributor.authorYen Kongen_US
dc.description.abstract© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. Antibacterial hydrogels based on poly(sodium 2-acrylamido-2-methylpropane sulfonate) and gelatin and incorporating chlorhexidine gluconate (CHG) as a drug were fabricated. The work focused on the effects of varying the CHG concentration. The hydrogel containing 0.02% w/v of CHG was chosen as the drug-loaded hydrogel for comparison with the hydrogel with no drug. From the drug release results, it was found that only 2-5% CHG was released, indicating that the CHG strongly interacted with the hydrogel network. To confirm the antibacterial efficiency of the hydrogels, the shake-flask method and scanning electron microscopy were employed. The antibacterial activity of the drug-loaded hydrogels showed a 7-log reduction for S. aureus gram-positive and a 5-6-log reduction for E. coli gram-negative bacteria. In addition, an MTT assay was performed to evaluate their potential cytotoxicity and showed a percentage cell viability after 24 h of more than 70% which classified them as being non-cytotoxic. In conclusion, the hydrogels containing CHG are considered as one of the interesting candidates for potential biomedical use as antibacterial wound dressings. Further in vivo investigations are planned.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemical Engineeringen_US
dc.subjectMaterials Scienceen_US
dc.titleSynthesis of polymeric hydrogels incorporating chlorhexidine gluconate as antibacterial wound dressingsen_US
article.title.sourcetitleJournal of Biomaterials Science, Polymer Editionen_US Mai Universityen_US Regeneration Systems, Inc.en_US Solutions LLCen_US
Appears in Collections:CMUL: Journal Articles

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