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dc.contributor.authorAtcharaporn Ontawongen_US
dc.contributor.authorChutima Srimaroengen_US
dc.contributor.authorOranit Boonphangen_US
dc.contributor.authorManussabhorn Phatsaraen_US
dc.contributor.authorDoungporn Amornlerdpisonen_US
dc.contributor.authorAcharaporn Duangjaien_US
dc.date.accessioned2020-04-02T15:17:50Z-
dc.date.available2020-04-02T15:17:50Z-
dc.date.issued2019-01-01en_US
dc.identifier.issn13475215en_US
dc.identifier.issn09186158en_US
dc.identifier.other2-s2.0-85074545896en_US
dc.identifier.other10.1248/bpb.b19-00199en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074545896&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/68048-
dc.description.abstract© 2019 The Pharmaceutical Society of Japan. Spirogyra neglecta (SN), commonly named "Tao" in Thai, is a genus of filamentous green macroalgae. SN contains polyphenols such as isoquercetin, catechin, hydroquinone and kaempferol. These constituents exhibit beneficial effects including anti-oxidant, anti-gastric ulcer, anti-hyperglycaemia and anti-hyperlipidaemia in both in vitro and in vivo models. Whether SN extract (SNE) has an anti-inflammatory effect in vivo remains unclear. This study examined the effect of SNE on renal function and renal organic transport in lipopolysaccharide (LPS)-induced renal inflammation in rats. Rats were randomised and divided into normal saline (NS), NS supplemented with 1000 mg/kg body weight (BW) of SNE (NS + SNE), intraperitoneally injected with 12 mg/kg BW of LPS and LPS treated with 1000 mg/kg BW of SNE (LPS + SNE). Biochemical parameters in serum and urine, lipid peroxidation concentration, kidney function and renal organic anion and cation transports were determined. LPS-injected rats developed renal injury and inflammation by increasing urine microalbumin, total malondialdehyde (MDA) and inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-1β protein expression, respectively. In addition, uptake of renal organic anion, [3H]-oestrone sulphate (ES), was reduced in LPS-injected rats together with increased expression of organic anion transporter 3 (Oat3). However, the renal injury and inflammation, as well as impaired Oat3 function and protein expression, were restored in LPS + SNE rats. Accordingly, SNE could be developed as nutraceutical product to prevent inflammation-induced nephrotoxicity.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleSpirogyra neglecta aqueous extract attenuates lps-induced renal inflammationen_US
dc.typeJournalen_US
article.title.sourcetitleBiological and Pharmaceutical Bulletinen_US
article.volume42en_US
article.stream.affiliationsUniversity of Phayaoen_US
article.stream.affiliationsMaejo Universityen_US
article.stream.affiliationsChiang Mai Universityen_US
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