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dc.contributor.authorRatana Sapbamreren_US
dc.contributor.authorSupakit Khacha-Anandaen_US
dc.contributor.authorNalin Sittitoonen_US
dc.contributor.authorKlintean Wunnapuken_US
dc.contributor.authorMathuramat Seesenen_US
dc.contributor.authorSutthinee Sidthilawen_US
dc.contributor.authorJiraporn Chittrakulen_US
dc.contributor.authorBoonsita Suwannakulen_US
dc.description.abstract© Springer-Verlag GmbH Germany, part of Springer Nature 2019. Exposure to pesticides may have increased risk of oxidative stress and genetic damage and hence of development of chronic diseases. The aim of this longitudinal follow-up study is to compare oxidative stress and DNA damage between the pre-and post-pesticide application seasons among 56 male farmers. The study also investigated the factors associated with changes in oxidative stress, DNA damage, and health symptoms during the pesticide application season. The eligibility criteria for the subjects were men aged between 25 and 55 years, applied pesticide mixtures during May and June 2018, and healthy without current illness. Ten milliliters of venous blood samples was collected twice from each subject in the pre-and post-pesticide application seasons for determination of superoxide dismutase (SOD), 8-hydroxy-2′-deoxyguanosine (8-OHdG), comet tail length, and comet tail moment. The remarkable findings included a statistically significant increase in SOD activity during the pesticide application season (P < 0.001). However, there were no statistical differences in 8-OHdG, comet tail length, and comet tail moment. When we analyzed the factors associated with changes in SOD activity during the pesticide application season by using linear regression analysis, working hours on the farm (B ± SE. = 0.790 ± 0.341, P = 0.025) and planting activities (B ± SE. = 1.217 ± 0.504, P = 0.020) were associated with increase in SOD activity. Therefore, increase in SOD may be a consequence of oxidative damage induced by pesticide exposure and this marker may be used as an early warning for pesticide-induced acute and chronic toxicities.en_US
dc.subjectEnvironmental Scienceen_US
dc.titleA longitudinal follow-up study of oxidative stress and DNA damage among farmers exposed to pesticide mixturesen_US
article.title.sourcetitleEnvironmental Science and Pollution Researchen_US
article.volume26en_US of Phayaoen_US University of Technologyen_US Mai Universityen_US Hospitalen_US
Appears in Collections:CMUL: Journal Articles

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