Intraoperative intravenous dextrose administration and the incidence of nausea and vomiting after gynecologic laparoscopic surgery: a randomized double-blind controlled study

Abstract

during gynecologic laparoscopic surgery would reduce the incidence and severity of postoperative nausea and vomiting (PONV) compared with an equal volume of normal saline solution Methods A prospective randomized double blind controlled study was conducted. Eighty-six patients were randomized to receive either dextrose solution (n=42) or normal saline solution (n= 44). Bellville postoperative nausea and vomiting scores were recorded for the fi rst 24 hours after surgery. Results Fourteen of 44 patients (31.8%) in the normal saline solution group compared to 15 of 42 patients (35.7%) in the dextrose solution group developed postoperative nausea and vomiting (p =0.09). At each time point, the incidence and severity of PONV were similar. The patients in the dextrose solution group required more postoperative antiemetic medications (p =0.04). Blood glucose levels were signifi cantly higher in the dextrose solution group during both the intraoperative and postoperative periods (p < 0.01). Conclusions Intravenous dextrose administration does not reduce either the incidence or the severity of postoperative nausea and vomiting after laparoscopic gynecologic surgery but it does increase blood glucose level.