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dc.contributor.authorSalinee Jantrapiromen_US
dc.contributor.authorDe Shou Caoen_US
dc.contributor.authorJing W. Wangen_US
dc.contributor.authorHuey Hingen_US
dc.contributor.authorChristopher J. Taboneen_US
dc.contributor.authorKathryn Lantzen_US
dc.contributor.authorJ. Steven de Belleen_US
dc.contributor.authorYu Tong Qiuen_US
dc.contributor.authorHans M. Smiden_US
dc.contributor.authorMasamitsu Yamaguchien_US
dc.contributor.authorLee G. Fradkinen_US
dc.contributor.authorJasprina N. Noordermeeren_US
dc.contributor.authorSaranyapin Potikanonden_US
dc.description.abstract© 2019 Elsevier B.V. The Drosophila olfactory system provides an excellent model to elucidate the neural circuits that control behaviors elicited by environmental stimuli. Despite significant progress in defining olfactory circuit components and their connectivity, little is known about the mechanisms that transfer the information from the primary antennal olfactory receptor neurons to the higher order brain centers. Here, we show that the Dystrophin Dp186 isoform is required in the olfactory system circuit for olfactory functions. Using two-photon calcium imaging, we found the reduction of calcium influx in olfactory receptor neurons (ORNs) and also the defect of GABA A mediated inhibitory input in the projection neurons (PNs) in Dp186 mutation. Moreover, the Dp186 mutant flies which display a decreased odor avoidance behavior were rescued by Dp186 restoration in the Drosophila olfactory neurons in either the presynaptic ORNs or the postsynaptic PNs. Therefore, these results revealed a role for Dystrophin, Dp 186 isoform in gain control of the olfactory synapse via the modulation of excitatory and inhibitory synaptic inputs to olfactory projection neurons.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleDystrophin is required for normal synaptic gain in the Drosophila olfactory circuiten_US
article.title.sourcetitleBrain Researchen_US
article.volume1712en_US Mai Universityen_US of California, San Diegoen_US University of New York Brockporten_US of Nevada, Las Vegasen_US LLCen_US University and Research Centreen_US Institute of Technologyen_US University Medical Center - LUMCen_US of Massachusetts Medical Schoolen_US
Appears in Collections:CMUL: Journal Articles

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