Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/62942
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dc.contributor.authorPatchareeya Amputen_US
dc.contributor.authorChristian McSweeneyen_US
dc.contributor.authorSiripong Paleeen_US
dc.contributor.authorArintaya Phrommintikulen_US
dc.contributor.authorSiriporn C. Chattipakornen_US
dc.contributor.authorNipon Chattipakornen_US
dc.date.accessioned2018-12-14T03:41:54Z-
dc.date.available2018-12-14T03:41:54Z-
dc.date.issued2019-01-01en_US
dc.identifier.issn19506007en_US
dc.identifier.issn07533322en_US
dc.identifier.other2-s2.0-85056208509en_US
dc.identifier.other10.1016/j.biopha.2018.10.138en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056208509&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/62942-
dc.description.abstract© 2018 Elsevier Masson SAS Low density lipoprotein cholesterol (LDL-C) is a well-established risk factor for cardiovascular disease. Although there are several developed lipid lowering drugs such as statins and fenofibrates, many patients do not achieve an adequate response. Recently, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been developed as a new therapeutic strategy for cholesterol regulation. PCSK9 binds to low density lipoprotein receptors (LDLR) and initiates LDLR degradation, elevating LDL-C. Therefore, PCSK9 inhibition could exert beneficial effects on cardiovascular disease outcomes. This review comprehensively summarizes and discusses the effects of PCSK9 inhibitors on lipid metabolism and cardiovascular function comparatively with current lipid lowering drugs. This review also details essential information regarding the cardiovascular benefits of PCSK9 inhibition which could encourage further clinical studies.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleThe effects of proprotein convertase subtilisin/kexin type 9 inhibitors on lipid metabolism and cardiovascular functionen_US
dc.typeJournalen_US
article.title.sourcetitleBiomedicine and Pharmacotherapyen_US
article.volume109en_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsUniversity of Manchesteren_US
Appears in Collections:CMUL: Journal Articles

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