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dc.contributor.authorChiramet Auranwiwaten_US
dc.contributor.authorRoonglawan Rattanajaken_US
dc.contributor.authorSumalee Kamchonwongpaisanen_US
dc.contributor.authorSurat Laphookhieoen_US
dc.contributor.authorStephen G. Pyneen_US
dc.contributor.authorThunwadee Limtharakulen_US
dc.description.abstract© 2018 Elsevier B.V. The phytochemical investigation of the fruit extracts of Uvaria cherrevensis led to the isolation and characterization of four new C-benzyl flavonoids; cherrevenones A-D (1–4) together with 11 known compounds. The isolated compounds were characterized using spectroscopic techniques. Compounds 1, 3, 5 and 11 showed moderate inhibitory activities against the P. falciparum strains TM4/8.2 and K1CB1 with IC50 values ranging from 21.0 ± 3.10 – 33.7 ± 7.69 and 21.0 ± 5.44 – 43.5 ± 11.9 μM, respectively. Compounds 1, 2, 5, 10 and 11 exhibited strong cytotoxic activities against KB cells with IC50 values ranging from 0.60 ± 0.17 – 4.91 ± 2.69 μM which were similar to their cytotoxic activities found against Vero cells, except for compound 5, which was non-toxic to Vero cells.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleFour new C-benzyl flavonoids from the fruit of Uvaria cherrevensisen_US
article.volume130en_US Mai Universityen_US of Wollongongen_US National Center for Genetic Engineering and Biotechnologyen_US Fah Luang Universityen_US
Appears in Collections:CMUL: Journal Articles

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