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dc.contributor.authorPimlak Charoenkwanen_US
dc.contributor.authorChanane Wanapiraken_US
dc.contributor.authorPattra Thanarattanakornen_US
dc.contributor.authorRattanaporn Sekararithien_US
dc.contributor.authorRattika Sae-Tungen_US
dc.contributor.authorSomjai Sittipreechacharnen_US
dc.contributor.authorTorpong Sanguansermsrien_US
dc.description.abstractCoinheritance of α-thalassemia and hemoglobin E (Hb E) is prevalent in Thailand, where the gene frequencies of thalassemia and hemoglobinopathies are high. Hb E carriers with, concomitant inheritance of α-thalassemia 1 are known to have a lower level of Hb E. In this study, we reviewed the Hb E levels in Hb E carriers, who either had or did not have Southeast Asian (SEA)-type α-thalassemia, in order to seek a Hb E level that may be used as a predictor for concomitant α-thalassemia carrier status. The Hb E levels as measured by microcolumn chromatography in 844 Hb E carriers detected during a prenatal screening program for severe thalassemia at Chiang Mai University Hospital were reviewed. Hb E levels ranged from 12.3-35.0% (23.3±3.1%) in 751 Hb E carriers without SEA-type α-thalassemia and from 11.6-32.0% (17.0±3.7%) in 93 concomitant Hb E and SEA-type α-thalassemia carriers. The difference was significant (p<0.01). However, the absence of SEA-type α-thalassemia could not be predicted by the higher Hb E level alone, as 3% of double heterozygotes demonstrated a level of more than 25%. Our study confirms a lower Hb E level in double heterozygotes with Hb E and SEA-type α-thalassemia. Nevertheless, the difference does not provide sufficient discriminatory power for the reliable exclusion of α-thalassemia status.en_US
dc.titleHemoglobin E levels in double heterozygotes of hemoglobin E and sea-type α-thalassemiaen_US
article.title.sourcetitleSoutheast Asian Journal of Tropical Medicine and Public Healthen_US
article.volume36en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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