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dc.contributor.authorVictoria Warden_US
dc.contributor.authorBranwen J. Hennigen_US
dc.contributor.authorKouzo Hiraien_US
dc.contributor.authorHideki Taharaen_US
dc.contributor.authorAkihiro Tamorien_US
dc.contributor.authorRitu Dawesen_US
dc.contributor.authorMineki Saitoen_US
dc.contributor.authorCharles Banghamen_US
dc.contributor.authorHenry Stephensen_US
dc.contributor.authorAnne E. Goldfelden_US
dc.contributor.authorWarunee Kunachiwaen_US
dc.contributor.authorNipapan Leetrakoolen_US
dc.contributor.authorJulian Hopkinen_US
dc.contributor.authorSarah Dunstanen_US
dc.contributor.authorAdrian Hillen_US
dc.contributor.authorWalter Bodmeren_US
dc.contributor.authorPeter C.L. Beverleyen_US
dc.contributor.authorElma Z. Tchilianen_US
dc.description.abstractCD45 is crucial for normal lymphocyte signalling, and altered CD45 expression has major effects on immune function. Both mice and humans lacking CD45 expression are severely immunodeficient, and single-nucleotide polymorphisms in the CD45 gene that cause altered splicing have been associated with autoimmune and infectious diseases. Recently, we identified an exon 6 A138G polymorphism resulting in an increased proportion of activated CD45RO T cells and altered immune function. Here we report a significantly reduced frequency of the 138G allele in hepatitis C Japanese patients and a possibly reduced frequency in type I diabetes. The allele is widely distributed in the Far East and India, indicating that it may have a significant effect on disease burden in a large part of the human population. © Springer-Verlag 2006.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleGeographical distribution and disease associations of the CD45 exon 6 138G varianten_US
article.volume58en_US Radcliffe Hospitalen_US Trust Centre for Human Geneticsen_US City Universityen_US Jenner Institute for Vaccine Researchen_US University Faculty of Medicineen_US College Londonen_US of Urology and Nephrologyen_US Disease Institute, Inc. Bostonen_US Mai Universityen_US Universityen_US
Appears in Collections:CMUL: Journal Articles

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