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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Victoria Ward | en_US |
dc.contributor.author | Branwen J. Hennig | en_US |
dc.contributor.author | Kouzo Hirai | en_US |
dc.contributor.author | Hideki Tahara | en_US |
dc.contributor.author | Akihiro Tamori | en_US |
dc.contributor.author | Ritu Dawes | en_US |
dc.contributor.author | Mineki Saito | en_US |
dc.contributor.author | Charles Bangham | en_US |
dc.contributor.author | Henry Stephens | en_US |
dc.contributor.author | Anne E. Goldfeld | en_US |
dc.contributor.author | Warunee Kunachiwa | en_US |
dc.contributor.author | Nipapan Leetrakool | en_US |
dc.contributor.author | Julian Hopkin | en_US |
dc.contributor.author | Sarah Dunstan | en_US |
dc.contributor.author | Adrian Hill | en_US |
dc.contributor.author | Walter Bodmer | en_US |
dc.contributor.author | Peter C.L. Beverley | en_US |
dc.contributor.author | Elma Z. Tchilian | en_US |
dc.date.accessioned | 2018-09-11T08:54:42Z | - |
dc.date.available | 2018-09-11T08:54:42Z | - |
dc.date.issued | 2006-04-01 | en_US |
dc.identifier.issn | 00937711 | en_US |
dc.identifier.other | 2-s2.0-33645460228 | en_US |
dc.identifier.other | 10.1007/s00251-006-0099-0 | en_US |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33645460228&origin=inward | en_US |
dc.identifier.uri | http://cmuir.cmu.ac.th/jspui/handle/6653943832/61534 | - |
dc.description.abstract | CD45 is crucial for normal lymphocyte signalling, and altered CD45 expression has major effects on immune function. Both mice and humans lacking CD45 expression are severely immunodeficient, and single-nucleotide polymorphisms in the CD45 gene that cause altered splicing have been associated with autoimmune and infectious diseases. Recently, we identified an exon 6 A138G polymorphism resulting in an increased proportion of activated CD45RO T cells and altered immune function. Here we report a significantly reduced frequency of the 138G allele in hepatitis C Japanese patients and a possibly reduced frequency in type I diabetes. The allele is widely distributed in the Far East and India, indicating that it may have a significant effect on disease burden in a large part of the human population. © Springer-Verlag 2006. | en_US |
dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
dc.subject | Immunology and Microbiology | en_US |
dc.title | Geographical distribution and disease associations of the CD45 exon 6 138G variant | en_US |
dc.type | Journal | en_US |
article.title.sourcetitle | Immunogenetics | en_US |
article.volume | 58 | en_US |
article.stream.affiliations | John Radcliffe Hospital | en_US |
article.stream.affiliations | Wellcome Trust Centre for Human Genetics | en_US |
article.stream.affiliations | Osaka City University | en_US |
article.stream.affiliations | Edward Jenner Institute for Vaccine Research | en_US |
article.stream.affiliations | Kagoshima University Faculty of Medicine | en_US |
article.stream.affiliations | Imperial College London | en_US |
article.stream.affiliations | Institute of Urology and Nephrology | en_US |
article.stream.affiliations | Immune Disease Institute, Inc. Boston | en_US |
article.stream.affiliations | Chiang Mai University | en_US |
article.stream.affiliations | Swansea University | en_US |
article.stream.affiliations | UCL | en_US |
Appears in Collections: | CMUL: Journal Articles |
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