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dc.contributor.authorSomdet Srichairatanakoolen_US
dc.contributor.authorSakaewan Ounjaijeanen_US
dc.contributor.authorChonthida Thephinlapen_US
dc.contributor.authorUdompun Khansuwanen_US
dc.contributor.authorChada Phisalpongen_US
dc.contributor.authorSuthat Fucharoenen_US
dc.description.abstractSecondary iron overload is found in β-thalassemia (thal) patients because of increased dietary iron absorption and multiple blood transfusions. Excessive iron catalyzes free-radical generation, leading to oxidative damage and vital organ dysfunction. Non-transferrin-bound iron (NTBI) detected in thalassemic plasma is highly toxic and chelatable. Though used to treat iron overload, desferrioxamine (DFO) and deferiprone (L1) also have adverse effects. Green tea (GT) shows many pharmacological effects, particularly antioxidative and iron-chelating capacities. This study was performed to investigate the ability of GT extracts to reduce plasma NTBI concentration and oxidative stress in vitro. The Fe3+was found to bind to GT crude extract and form a complex. Green tea crude extract time- and dose-dependently decreased plasma NTBI concentration and counteracted the increase of oxidative stress in both Fe2+-EDTA-treated human plasma and erythrocytes. Green tea is a bifunctional natural product that could be relevant for management of iron overload and oxidative stress. Copyright © Taylor & Francis Group, LLC.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleIron-chelating and free-radical scavenging activities of microwave-processed green tea in iron overloaden_US
article.volume30en_US Mai Universityen_US Government Pharmaceutical Organizationen_US Institute of Science and Technology for Research and Development, Mahidol Universityen_US
Appears in Collections:CMUL: Journal Articles

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