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dc.contributor.authorPattara Khamrinen_US
dc.contributor.authorNiwat Maneekarnen_US
dc.contributor.authorSupatra Peerakomeen_US
dc.contributor.authorWisoot Chan-iten_US
dc.contributor.authorFumihiro Yagyuen_US
dc.contributor.authorShoko Okitsuen_US
dc.contributor.authorHiroshi Ushijimaen_US
dc.description.abstractA novel and unusual strain of porcine rotavirus (PoRV) CMP034 was isolated from a 7-week-old piglet during the epidemiological survey of porcine rotavirus infection in Chiang Mai province, Thailand from June 2000 to July 2001. Molecular characterization of gene VP4 by sequence analysis showed a low level of amino acid sequence identity, ranging from 56.7% to 76.6%, while comparison of VP8* portion showed 41.8% to 69.9% identity, with the 26 P genotypes recognized to date. Phylogenetic analysis of the VP4 sequence revealed that CMP034 was only distantly related to the other 26 P genotypes and was located in a separate branch. Sequence analysis of gene VP7 showed the highest level of amino acid identity (94.7%) with the PoRV G2-like reference strain 34461-4 but a lower level of identity with those of human G2 rotaviruses, ranging from 87.7% to 88.0%. Phylogenetic analysis of gene VP7 revealed two major lineages among G2 rotavirus strains based on the host origin. PoRV strain CMP034 clustered exclusively with G2-like PoRV strain 34461-4 in a novel lineage that is distinct from the major G2 human lineage. Moreover, strain CMP034 displayed a porcine-like VP6 and NSP5/6 with subgroup I specificity, while bearing an NSP4 with some genetic group B human-like characteristics. These findings provide evidence that CMP034 should be considered as a novel VP4 genotype P[27]. © 2006 Elsevier Inc. All rights reserved.en_US
dc.subjectImmunology and Microbiologyen_US
dc.titleNovel porcine rotavirus of genotype P[27] shares new phylogenetic lineage with G2 porcine rotavirus strainen_US
article.volume361en_US of International Healthen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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