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dc.contributor.authorSodsai Tovanabutraen_US
dc.contributor.authorGustavo H. Kijaken_US
dc.contributor.authorChris Beyreren_US
dc.contributor.authorChristiana Gammon-Richardsonen_US
dc.contributor.authorSupachai Sakkhachornphopen_US
dc.contributor.authorTasanai Vongchaken_US
dc.contributor.authorJaroon Jittiwutikarnen_US
dc.contributor.authorMyat Htoo Razaken_US
dc.contributor.authorEric Sanders-Buellen_US
dc.contributor.authorMerlin L. Robben_US
dc.contributor.authorVinai Suriyanonen_US
dc.contributor.authorDeborah L. Birxen_US
dc.contributor.authorNelson L. Michaelen_US
dc.contributor.authorDavid D. Celentanoen_US
dc.contributor.authorFrancine E. Mccutchanen_US
dc.description.abstractIn Thailand, the circulating HIV-1 strains include CRF01_AE, subtype B, and their recombinants. Genotyping and full-genome sequencing had previously identified circulating recombinant form CRF15_01B within a cohort of 347 HIV-1-infected individuals enrolled in the Opiate Users Research (OUR) study in northern Thailand. Using an improved MHAbce in six to eight genome regions and archived OUR serum samples, seven strains were identified with a new and complex 01/B recombinant pattern in common, different from that of CRF15_01B. Complete sequencing of three strains, amplified from serum as overlapping half-genomes, confirmed their common recombinant structure, mostly CRF01_AE, but with segments of subtype B in pol and gp41, plus a region of frequent 01/B crossovers in pol. OUR strains 1969P, 2275P, and 2478P were from individuals without direct epidemiological linkage and thus establish CRF34_01B. More comprehensive HIV-1 prevention and treatment programs in IDU can help to limit the growing complexity of HIV-1 strains in Thailand. © Mary Ann Liebert, Inc.en_US
dc.subjectImmunology and Microbiologyen_US
dc.titleIdentification of CRF34_01B, a second circulating recombinant form unrelated to and more complex than CRF15_01B, among injecting drug users in northern Thailanden_US
article.title.sourcetitleAIDS Research and Human Retrovirusesen_US
article.volume23en_US Military HIV Research Programen_US Hopkins Bloomberg School of Public Healthen_US Mai Universityen_US Drug Treatment Centeren_US Reed Army Institute of Researchen_US for Disease Control and Preventionen_US
Appears in Collections:CMUL: Journal Articles

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