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dc.contributor.authorThongchai Taechowisanen_US
dc.contributor.authorChunhua Luen_US
dc.contributor.authorYuemao Shenen_US
dc.contributor.authorSaisamorn Lumyongen_US
dc.date.accessioned2018-09-10T03:59:38Z-
dc.date.available2018-09-10T03:59:38Z-
dc.date.issued2007-10-01en_US
dc.identifier.issn14786427en_US
dc.identifier.issn14786419en_US
dc.identifier.other2-s2.0-34548709017en_US
dc.identifier.other10.1080/14786410601129671en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34548709017&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/60784-
dc.description.abstractThis research was undertaken to find the in vitro inflammatory action of 5,7-dimethoxy-4- p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. We investigated the effects of 5,7-dimethoxy-4-p- methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin not only on the formation of nitric oxide (NO), PGE2, TNF-α, IL-6 and IL-1β, but also on inducible NO synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar fashion was also observed when LPS-induced PGE2release and COX-2 expression were tested. The significant inhibitory effects were shown in concentration-dependent manners. In addition, 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin also mildly but significantly reduced the formation of TNF-α. These findings support the application of 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin as anti-inflammatory agents.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.titleIn vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cellsen_US
dc.typeJournalen_US
article.title.sourcetitleNatural Product Researchen_US
article.volume21en_US
article.stream.affiliationsSilpakorn Universityen_US
article.stream.affiliationsXiamen Universityen_US
article.stream.affiliationsKunming Institute of Botany Chinese Academy of Sciencesen_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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