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dc.contributor.authorSeewaboon Sireeratawongen_US
dc.contributor.authorNirush Lertprasertsukeen_US
dc.contributor.authorUmarat Srisawaten_US
dc.contributor.authorAmornat Thuppiaen_US
dc.contributor.authorAnongnad Ngamjariyawaten_US
dc.contributor.authorNadthaganya Suwanlikhiden_US
dc.contributor.authorKanjana Jaijoyen_US
dc.description.abstractThe study was carried out to evaluate acute and subchronic toxicities of the water extract from Tiliacora triandra (Colebr.) Diels. A single oral administration of the extract at a dose of 5,000 mg/kg body weight (5 males, 5 females) did not produce signs of toxicity, behavioral changes, mortality, changes on gross appearance or histopathological changes of internal organs. The subchronic toxicity was determined by oral feeding both male and female rats (10 males, 10 females) daily with the test substance at the doses of 300, 600 and 1,200 mg/kg body weight continuously for 90 days. The examinations of signs, animal behavior and health monitoring showed no abnormalities in the test groups as compared to the controls. The test and control groups (on the 90 th day) and the satellite group (on the 118"' day) were analyzed by measuring their final body and organ weights, taking necropsy, and examining hematology, blood clinical chemistry and histopathology. The results suggest that the water extract from the T. triandra does not cause acute or subchronic toxicities in either male or female rats.en_US
dc.titleAcute and subchronic toxicity study of the water extract from Tiliacora triandra (Colebr.) Diels in ratsen_US
article.title.sourcetitleSongklanakarin Journal of Science and Technologyen_US
article.volume30en_US Universityen_US of Medicine, Thammasat Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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