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dc.contributor.authorKevalee Unachaken_US
dc.contributor.authorPranoot Tanpaiboonen_US
dc.contributor.authorYupada Pongproten_US
dc.contributor.authorRekwan Sittivangkulen_US
dc.contributor.authorSuchaya Silvilairaten_US
dc.contributor.authorPrapai Dejkhamronen_US
dc.contributor.authorJutamas Sudasnaen_US
dc.description.abstractObjective: To evaluate thyroid function in children with Down's syndrome, and to ascertain the presence of a relationship between overt thyroid diseases and congenital anomalies. Material and Method: One hundred and forty Down's syndrome patients, aged from 3 days to 13 years 9 months, were evaluated for karyotype, thyroid functions and the coexistence of congenital anomalies. Results: Trisomy 21 was found in the majority of cases (95.7%). Fifty-six patients (40%) had abnormal thyroid functions: 53 (37.9%) hypothyroidism and 3 (2.1%) hyperthyroidism. Ten patients (7.1%) were diagnosed with overt thyroid disease: congenital hypothyroidism 3.6%, acquired hypothyroidism associated autoimmune thyroiditis 1.4% and hyperthyroidism 2.1%. None of the patients with congenital hypothyroidism had athyreosis or ectopic thyroid gland. Sub-clinical hypothyroidism accounted for 32.9% of all cases; 10.7% showed a spontaneous decrease to normal TSH levels and 13.6% had persistently elevated TSH levels with the median follow-up time of 6 and 12 months, respectively. Congenital heart disease, gastrointestinal anomalies and hematological disease were found in 73.6, 10 and 3.6 percent of patients, respectively. There was no statistical correlation between the coexistence of cardiovascular or gastrointestinal disease in Down's syndrome patients with overt thyroid diseases or sub-clinical hypothyroidism to those having normal thyroid functions. Conclusion: Sub-clinical hypothyroidism was the most common thyroid abnormality in children with Down's syndrome. A longitudinal and timely-scheduled evaluation of thyroid function is needed to establish the natural course of this abnormality and the proper management guideline.en_US
dc.titleThyroid functions in children with Down's syndromeen_US
article.title.sourcetitleJournal of the Medical Association of Thailanden_US
article.volume91en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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