Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/59092
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dc.contributor.authorKantaporn Kheawfuen_US
dc.contributor.authorSurachai Pikulkaewen_US
dc.contributor.authorThomas Radesen_US
dc.contributor.authorAnette Müllertzen_US
dc.contributor.authorSiriporn Okonogien_US
dc.date.accessioned2018-09-05T04:37:56Z-
dc.date.available2018-09-05T04:37:56Z-
dc.date.issued2018-08-01en_US
dc.identifier.issn17732247en_US
dc.identifier.other2-s2.0-85047620041en_US
dc.identifier.other10.1016/j.jddst.2018.05.028en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047620041&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/59092-
dc.description.abstract© 2018 Elsevier B.V. This study was carried out to develop clove oil nanoformulations with reduced or no ethanol to increase the aqueous miscibility of clove oil for use in fish anesthesia. The droplets of clove oil nanoemulsion (C-NE) and self-microemulsifying drug delivery systems (C-SMEDDS) were characterized using photon correlation spectroscopy and transmission electron microscope. The droplet size of C-NE containing 10–20% clove oil and 5–15% polysorbate 20 was 23–133 nm, whereas that of C-SMEDDS composed of 10% clove oil and 90% polysorbate 20 or 10% clove oil and 60% polysorbate 20 and 30% ethanol or isopropanol was 11–44 nm. The droplets were roughly spherical. After stored for 90 days, at 4 °C, most C-NE and C-SMEDDS showed no change in appearance and droplet size. Low degradation rate of eugenol, a major compound of clove oil, was found at this temperature. Anesthesia induction times of C-NE composed of 10–20% clove oil and 5–10% polysorbate 20, and C-SMEDDS composed of 60% polysorbate 20 and 30% co-solvent in goldfish were 4.0 ± 0.6 min and 3.8 ± 0.9 min, respectively, significantly shorter than that of clove oil ethanolic solution (5.0 ± 0.9 min), but there was no significant difference in the recovery time.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleDevelopment and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systemsen_US
dc.typeJournalen_US
article.title.sourcetitleJournal of Drug Delivery Science and Technologyen_US
article.volume46en_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsKobenhavns Universiteten_US
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