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dc.contributor.authorDiana F. Clarkeen_US
dc.contributor.authorMartina Penazzatoen_US
dc.contributor.authorEdmund Capparellien_US
dc.contributor.authorTim R. Cresseyen_US
dc.contributor.authorGeorge Siberryen_US
dc.contributor.authorNandita Sugandhien_US
dc.contributor.authorMark Mirochnicken_US
dc.description.abstract© 2017 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Antiretroviral drugs are used in neonates for prevention and treatment of HIV infection. Use of antiretrovirals to prevent perinatal HIV transmission is well established. Early identification of neonates infected with HIV and rapid initiation of combination antiretroviral treatment during the neonatal period is now recommended by WHO and DHHS. However, few antiretrovirals are available in formulations suitable for neonates and there are limited safety and pharmacokinetic data for most antiretrovirals in neonates. Areas covered: We summarize existing neonatal antiretroviral safety and pharmacokinetic information and discuss implementation considerations for programs providing antiretrovirals to neonates and young infants. Expert commentary: Antiretrovirals currently recommended by WHO for use in neonates are zidovudine, lamivudine, lopinavir/ritonavir, nevirapine, and raltegravir. Significant implementation challenges exist to the widespread use of these antiretrovirals in neonates. Optimal, feasible treatment of HIV-exposed and HIV-infected newborns will require development of practical neonatal dosage forms and their study in neonates for a wide range of antiretrovirals.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titlePrevention and treatment of HIV infection in neonates: evidence base for existing WHO dosing recommendations and implementation considerationsen_US
article.title.sourcetitleExpert Review of Clinical Pharmacologyen_US
article.volume11en_US Medical Centeren_US University School of Medicineen_US Mondiale de la Santeen_US of California, San Diegoen_US Mai Universityen_US School of Public Healthen_US of Liverpoolen_US States Department of Stateen_US University in the City of New Yorken_US
Appears in Collections:CMUL: Journal Articles

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