Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/58772
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKriangkrai Chawansuntatien_US
dc.contributor.authorKanokporn Chaiklangen_US
dc.contributor.authorRomanee Chaiwarithen_US
dc.contributor.authorJutarat Praparattanapanen_US
dc.contributor.authorKhuanchai Supparatpinyoen_US
dc.contributor.authorJiraprapa Wipasaen_US
dc.date.accessioned2018-09-05T04:30:37Z-
dc.date.available2018-09-05T04:30:37Z-
dc.date.issued2018-01-01en_US
dc.identifier.issn23147156en_US
dc.identifier.issn23148861en_US
dc.identifier.other2-s2.0-85048676705en_US
dc.identifier.other10.1155/2018/8350862en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048676705&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/58772-
dc.description.abstractCopyright © 2018 Kriangkrai Chawansuntati et al. We investigated cytokine production and expression of degranulation marker CD107a after different strategies of hepatitis B virus (HBV) vaccination in human immunodeficiency virus-infected individuals, which were three doses of 20 μg (standard dose group), four doses of 20 μg (four doses group), or four doses of 40 μg (four double doses group), compared to standard dose vaccination in healthy controls. PBMCs collected at different time points were stimulated in vitro with recombinant hepatitis B surface antigen and analyzed by flow cytometry. There was an increase in TNF-α production of total and memory CD4+ T cells at 7 months after vaccination in healthy controls compared to the HIV+ group, which received the same standard vaccination regimen. An increase in the IL-2-producing memory CD4+ T cells in the healthy control group was also observed at 7 months after vaccination. No differences were observed between the healthy controls and both groups of four doses at any time point of study. These results suggest that the standard HBV vaccination schedule might induce better production of TNF-α and IL-2 from CD4+ T cells in healthy individuals. Modification of HBV vaccination schedule by increasing the frequency and/or dosage may improve the CMI response in HIV-infected individuals.en_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleHepatitis B vaccination induced TNF-α- and IL-2-producing T cell responses in HIV. Healthy individuals higher than in HIV+ individuals who received the same vaccination regimenen_US
dc.typeJournalen_US
article.title.sourcetitleJournal of Immunology Researchen_US
article.volume2018en_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.