Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/58436
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dc.contributor.authorNatnicha Jommaneeen_US
dc.contributor.authorChalathorn Chanthaden_US
dc.contributor.authorKiattikhun Manokruangen_US
dc.date.accessioned2018-09-05T04:24:04Z-
dc.date.available2018-09-05T04:24:04Z-
dc.date.issued2018-10-15en_US
dc.identifier.issn01448617en_US
dc.identifier.other2-s2.0-85049308081en_US
dc.identifier.other10.1016/j.carbpol.2018.06.099en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049308081&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/58436-
dc.description.abstract© 2018 Elsevier Ltd In this present work, stimuli responsive polymers that can respond to the temperature and pH of the environment were prepared. A series of temperature responsive diblock copolymers based on poly(ethylene glycol) methyl ether (mPEG) and ε-caprolactone (CL) were synthesized. Subsequently, the diblock copolymers were grafted onto chitosan, a pH responsive biopolymer. These chitosan-graft-(mPEG-block-PCL) (chitosan-g-(mPEG-b-PCL)) graft copolymers were structurally characterized by1H NMR and FTIR and their sol-gel phase transitions were analyzed by the test tube inversion method as well as dynamic rheological measurements. These chitosan-g-(mPEG-b-PCL) graft copolymers demonstrated tunable temperature and pH responsive sol-gel phase transitions that correspond well with body temperature and pH of acidic tumor microenvironments. Gelation temperature (Tgel) decreased with increasing pH of the system, increasing PCL composition in the diblock copolymers, increasing solution concentration and decreasing grafting content of the diblock copolymers on chitosan. The graft copolymer hydrogels successfully showed the sustained release of both doxorubicin and curcumin for up to 2 weeks. The designed system was based on chitosan-g-(mPEG-b-PCL) graft copolymers, of which chitosan showed pH responsive properties and mPEG-b-PCL acted as a temperature sensitive moiety. In addition, mPEG and PCL are recognized as biocompatible polymers and chitosan has been engaged in various pharmaceutical research. Thus, this system could be considered an alternative choice for drug delivery applications.en_US
dc.subjectChemistryen_US
dc.subjectMaterials Scienceen_US
dc.titlePreparation of injectable hydrogels from temperature and pH responsive grafted chitosan with tuned gelation temperature suitable for tumor acidic environmenten_US
dc.typeJournalen_US
article.title.sourcetitleCarbohydrate Polymersen_US
article.volume198en_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsThailand National Science and Technology Development Agencyen_US
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