Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/57839
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dc.contributor.authorAmy E. Greeren_US
dc.contributor.authorSan San Ouen_US
dc.contributor.authorEthan Wilsonen_US
dc.contributor.authorEstelle Piwowar-Manningen_US
dc.contributor.authorMichael S. Formanen_US
dc.contributor.authorMarybeth McCauleyen_US
dc.contributor.authorTheresa Gambleen_US
dc.contributor.authorCholticha Ruangyuttikarnen_US
dc.contributor.authorMina C. Hosseinipouren_US
dc.contributor.authorNagalingeswaran Kumarasamyen_US
dc.contributor.authorMulinda Nyirendaen_US
dc.contributor.authorBeatriz Grinsztejnen_US
dc.contributor.authorJose Henrique Pilottoen_US
dc.contributor.authorNatthapol Kosashunhananen_US
dc.contributor.authorMarineide Gonçalves De Meloen_US
dc.contributor.authorJoseph Makhemaen_US
dc.contributor.authorVictor Akeloen_US
dc.contributor.authorRavindre Panchiaen_US
dc.contributor.authorSharlaa Badal-Faesenen_US
dc.contributor.authorYing Q. Chenen_US
dc.contributor.authorMyron S. Cohenen_US
dc.contributor.authorSusan H. Eshlemanen_US
dc.contributor.authorChloe L. Thioen_US
dc.contributor.authorAlexandra Valsamakisen_US
dc.date.accessioned2018-09-05T03:50:44Z-
dc.date.available2018-09-05T03:50:44Z-
dc.date.issued2017-01-01en_US
dc.identifier.issn10779450en_US
dc.identifier.issn15254135en_US
dc.identifier.other2-s2.0-85026363946en_US
dc.identifier.other10.1097/QAI.0000000000001511en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026363946&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/57839-
dc.description.abstract© 2017 Wolters Kluwer Health, Inc. All rights reserved. Objective: Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(2)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a multinational clinical trial: HIV Prevention Trials Network (HPTN 052). Method: HBV infection status at enrollment was compared between HIV(+) (N = 1241) and HIV(-) (N = 1232) from 7 HBV-endemic countries. Hepatitis B e antigen and plasma HBV DNA were determined in cHB. Median CD4, median plasma HIV RNA, and prevalence of transaminase elevation were compared in HIV(+) with and without cHB. Significance was assessed with x2Fisher exact and median tests. Results: Among all participants, 33.6% had HBV exposure without cHB (8.9% isolated HBV core antibody, "HBcAb"; 24.7% HBcAb and anti-HB surface antibody positive, "recovered"), 4.3% had cHB, 8.9% were vaccinated, and 53.5% were uninfected. Data were similar among HIV(+) and HIV(2) except for isolated HBcAb, which was more prevalent in HIV(+) than HIV(2) [10.1% vs. 7.7%, P = 0.046]. Median HBV DNA trended higher in HIV(+) than in HIV(2). In HIV (+) with cHB versus those without cHB, transaminase elevations were more prevalent (alanine aminotransferase # grade 2, 12% vs. 5.2%, P = 0.037; aspartate aminotransferase # grade 2, 26% vs. 6.0%, P, 0.001), CD4 trended lower, and HIV RNA was similar. Conclusions: HBV infection status did not differ by HIV infection status. HIV co-infection was associated with isolated HBcAb and a trend of increased HBV DNA. In HIV, cHB was associated with mild transaminase elevations and a trend toward lower CD4.en_US
dc.subjectMedicineen_US
dc.titleComparison of hepatitis b virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052en_US
dc.typeJournalen_US
article.title.sourcetitleJournal of Acquired Immune Deficiency Syndromesen_US
article.volume76en_US
article.stream.affiliationsJohns Hopkins Hospitalen_US
article.stream.affiliationsFred Hutchinson Cancer Research Centeren_US
article.stream.affiliationsThe Johns Hopkins School of Medicineen_US
article.stream.affiliationsFHI 360en_US
article.stream.affiliationsFHI 360en_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsThe University of North Carolina at Chapel Hillen_US
article.stream.affiliationsUniversity of North Carolina Project Malawien_US
article.stream.affiliationsVHS Medical Centre Indiaen_US
article.stream.affiliationsUniversity of Malawi College of Medicineen_US
article.stream.affiliationsFundacao Oswaldo Cruzen_US
article.stream.affiliationsHospital Geral de Rio de Janeiroen_US
article.stream.affiliationsHospital Nossa Senhora da Conceicaoen_US
article.stream.affiliationsBotswana Harvard AIDS Institute Partnershipen_US
article.stream.affiliationsKenya Medical Research Instituteen_US
article.stream.affiliationsCenter for Disease Controlen_US
article.stream.affiliationsUniversity of Witwatersranden_US
article.stream.affiliationsJohns Hopkins Universityen_US
Appears in Collections:CMUL: Journal Articles

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