Five-year results for image-guided brachytherapy (IGBT) for cervical carcinoma: A report from single institute of Thailand

Abstract

© 2016 Cambridge University Press. Aim: To report of long-term results and toxicity profiles using image-guided brachytherapy (IGBT) combined with whole pelvic radiation therapy (WPRT) for cervical carcinoma. Materials and Methods: In total, 52 patients with locally advanced cervical carcinoma were enrolled into the study. WPRT was used to treat the clinical target volume (CTV) with a dose of 45-50·4 Gy in 23-28 fractions. IGBT using computed tomography was performed at the dose of 6·5-7 Gy×4 fractions to the minimum dose covering 90% of target volume (D90) of high-risk clinical target volume (HR-CTV). Results: The mean cumulative dose in equivalent doses of 2 Gy for the D90 of HR-CTV, dose at 2% at refereed volume (D2cc) of bladder, D2cc of rectum and D2cc of sigmoid colon were 92·4, 87·9, 69·6, and 72 Gy, respectively. At the median follow-up time of 61 months, the 5-year local control, disease-free survival, and overall survival rates were 96·2, 75 and 84·6% respectively. Two patients (3·8%) developed grade 3-4 gastrointestinal and two patients (3·8%) developed grade 3-4 genitourinal toxicities. Conclusion: The combination of WPRT plus IGBT showed very promising long-term results with excellent local control and toxicity profiles.