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dc.contributor.authorSatimai Aniwanen_US
dc.contributor.authorThawee Ratanachu Eken_US
dc.contributor.authorSupot Pongprasobchaien_US
dc.contributor.authorJulajak Limsrivilaien_US
dc.contributor.authorOng Ard Praisontarangkulen_US
dc.contributor.authorPises Pisespongsaen_US
dc.contributor.authorPisaln Mairiangen_US
dc.contributor.authorApichat Sangchanen_US
dc.contributor.authorJaksin Sottisupornen_US
dc.contributor.authorNaruemon Wisedopasen_US
dc.contributor.authorPinit Kullavanijayaen_US
dc.contributor.authorRungsun Rerknimitren_US
dc.description.abstractBackground: Selecting the cut-off point for the fecal immunochemical test (FIT) for colorectal cancer (CRC) screening programs is of prime importance. The balance between the test performance for detecting advanced neoplasia and the available colonoscopy resources should be considered. We aimed to identify the optimal cut-off of FIT for advanced neoplasia in order to minimize colonoscopy burden. Methods: We conducted a multi-center study in 6 hospitals from diverse regions of Thailand. Asymptomatic participants, aged 50-75 years, were tested with one-time quantitative FIT (OC-SENSOR, Eiken Chemical Co.,Ltd., Tokyo, Japan) and all participants underwent colonoscopy. We assessed test performance in detecting advanced neoplasia (advanced adenoma and CRC) and measured the burden of colonoscopy with different cut-offs [25 (FIT25), 50 (FIT50), 100 (FIT100), 150 (FIT150), and 200 (FIT200)ng/ml]. Results: Among 1,479 participants, advanced neoplasia and CRC were found in 137 (9.3%) and 14 (0.9%), respectively. From FIT25 to FIT200, the positivity rate decreased from 18% to 4.9%. For advanced neoplasia, an increased cut-off decreased sensitivity from 42.3% to 16.8% but increased specificity from 84.2% to 96.3%. The increased cut-off increased the positive predictive value (PPV) from 21.5% to 31.5%. However, all cut-off points provided a high negative predictive value (NPV) (> 90%). For CRC, the miss rate for FIT25 to FIT 150 was the same (n = 3, 21%), whereas that with FIT200 increased to 35% (n = 5). Conclusions: In a country with limited-colonoscopy resources, using FIT150 may be preferred because it offers both high PPV and NPV for advanced neoplasia detection. It could also decrease colonoscopy workload, while maintaining a CRC miss rate similar to those with lower cut-offs.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleThe optimal cut-off level of the fecal immunochemical test for colorectal cancer screening in a country with limited colonoscopy resources: A multi-center study from Thailanden_US
article.title.sourcetitleAsian Pacific Journal of Cancer Preventionen_US
article.volume18en_US Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn Universityen_US Universityen_US Mai Universityen_US Kaen Universityen_US of Songkla Universityen_US Universityen_US
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