Evaluation of phytochemical constituents and biological activities of leaves and stems of Marsdenia glabra Cost

Abstract

© All Rights Reserved. The leaf and stem-based methanol extracts of Marsdenia glabra Cost., which has been used as food in northern Thailand, were evaluated in term of their phytochemical profile and biological activities. The GC-MS results showed that various saturated and unsaturated fatty acid compounds were dominant in extracts acquired from both parts of the M. glabra plant. The highest level of total flavonoid and total phenolic contents were observed in the leaf extracts, and this extract also possessed the greatest antioxidant activity (DPPH; IC50513.38 μg/mL, FRAP; 15.17 mg gallic acid equivalent/g extract). Both the leaf and stem extracts could show slightly good antidiabetic activity when compared with acarbose, while showing high level of antihypertensive activity (approx. 87.00%), and also exhibiting antibacterial activity against methicillin-resistant Staphylococcus aureus. Both extracts did not display any adverse effects on human normal cells, while showing low inhibitory effects on human lung cancer cells. M. glabra extracts may be applied as active ingredient in food, pharmaceutical, cosmetic and other industries.