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dc.contributor.authorP. Vogelen_US
dc.contributor.authorR. W. Readen_US
dc.contributor.authorG. M. Hansenen_US
dc.contributor.authorD. R. Powellen_US
dc.contributor.authorP. N. Kantaputraen_US
dc.contributor.authorB. Zambrowiczen_US
dc.contributor.authorR. Brommageen_US
dc.date.accessioned2018-09-05T03:15:13Z-
dc.date.available2018-09-05T03:15:13Z-
dc.date.issued2016-07-01en_US
dc.identifier.issn15442217en_US
dc.identifier.issn03009858en_US
dc.identifier.other2-s2.0-84975089360en_US
dc.identifier.other10.1177/0300985815626778en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84975089360&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/56339-
dc.description.abstract© 2016, © The Author(s) 2016. Secreted WNT proteins control cell differentiation and proliferation in many tissues, and NOTUM is a secreted enzyme that modulates WNT morphogens by removing a palmitoleoylate moiety that is essential for their activity. To better understand the role this enzyme in development, the authors produced NOTUM-deficient mice by targeted insertional disruption of the Notum gene. The authors discovered a critical role for NOTUM in dentin morphogenesis suggesting that increased WNT activity can disrupt odontoblast differentiation and orientation in both incisor and molar teeth. Although molars in Notum-/-mice had normal-shaped crowns and normal mantle dentin, the defective crown dentin resulted in enamel prone to fracture during mastication and made teeth more susceptible to endodontal inflammation and necrosis. The dentin dysplasia and short roots contributed to tooth hypermobility and to the spread of periodontal inflammation, which often progressed to periapical abscess formation. The additional incidental finding of renal agenesis in some Notum-/-mice indicated that NOTUM also has a role in kidney development, with undiagnosed bilateral renal agenesis most likely responsible for the observed decreased perinatal viability of Notum-/-mice. The findings support a significant role for NOTUM in modulating WNT signaling pathways that have pleiotropic effects on tooth and kidney development.en_US
dc.subjectVeterinaryen_US
dc.titleDentin Dysplasia in Notum Knockout Miceen_US
dc.typeJournalen_US
article.title.sourcetitleVeterinary Pathologyen_US
article.volume53en_US
article.stream.affiliationsLexicon Pharmaceuticalsen_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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