Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/56232
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dc.contributor.authorWitthawat Ariyawutyakornen_US
dc.contributor.authorSiriwimon Saichaemchanen_US
dc.contributor.authorMarileila Varella Garciaen_US
dc.date.accessioned2018-09-05T03:11:09Z-
dc.date.available2018-09-05T03:11:09Z-
dc.date.issued2016-01-01en_US
dc.identifier.issn18379664en_US
dc.identifier.other2-s2.0-84976488784en_US
dc.identifier.other10.7150/jca.12663en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84976488784&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/56232-
dc.description.abstract© Ivyspring International Publisher. The MET signaling pathway plays an important role in normal physiology and its deregulation has proved critical for development of numerous solid tumors. Different technologies have been used to investigate the genomic and proteomic status of MET in cancer patients and its association with disease prognosis. Moreover, with the development of targeted therapeutic drugs, there is an urgent need to identify potential biomarkers for selection of patients who are more likely to derive benefit from these agents. Unfortunately, the variety of technical platforms and analysis criteria for diagnosis has brought confusion to the field and a lack of agreement in the evaluation of MET status as a prognostic or predictive marker for targeted therapy agents. We review the molecular mechanisms involved in the deregulation of the MET signaling pathway in solid tumors, the different technologies used for diagnosis, and the main factors that affect the outcome, emphasizing the urge for completing analytical and clinical validation of these tests. We also review the current clinical studies with MET targeted agents, which mostly focus on lung cancer.en_US
dc.subjectMedicineen_US
dc.titleUnderstanding and targeting MET signaling in solid tumors - are We there yet?en_US
dc.typeJournalen_US
article.title.sourcetitleJournal of Canceren_US
article.volume7en_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsPhramongkutklao College of Medicineen_US
article.stream.affiliationsUniversity of Colorado Health Sciences Centeren_US
Appears in Collections:CMUL: Journal Articles

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