1. CMU Intellectual Repository
  2. Academic Support Units
  3. Chiang Mai University Library
  4. CMUL: Journal Articles
Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/55894
Full metadata record
DC FieldValueLanguage
dc.contributor.authorIngrid A. Becken_US
dc.contributor.authorRachel Payanten_US
dc.contributor.authorNicole Ngo-Giang-Huongen_US
dc.contributor.authorWoottichai Khamduangen_US
dc.contributor.authorLaddawan Laomaniten_US
dc.contributor.authorGonzague Jourdainen_US
dc.contributor.authorLisa M. Frenkelen_US
dc.date.accessioned2018-09-05T03:03:24Z-
dc.date.available2018-09-05T03:03:24Z-
dc.date.issued2016-07-01en_US
dc.identifier.issn18790984en_US
dc.identifier.issn01660934en_US
dc.identifier.other2-s2.0-84962283790en_US
dc.identifier.other10.1016/j.jviromet.2016.03.014en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84962283790&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/55894-
dc.description.abstract© 2016 Elsevier B.V. Treatment of chronic hepatitis B virus (HBV) infection with lamivudine-monotherapy rapidly selects mutant variants in a high proportion of individuals. Monitoring lamivudine resistance by consensus sequencing is costly and insensitive for detection of minority variants. An oligonucleotide ligation assay (. OLA) for HBV lamivudine-resistance was developed and compared to consensus sequencing. Both assays detected drug resistance mutations in 35/64 (54.7%) specimens evaluated, and OLA detected minority mutants in an additional six (9.4%). OLA may offer a sensitive and inexpensive alternative to consensus sequencing for detection of HBV drug resistance in resource-limited settings.en_US
dc.subjectImmunology and Microbiologyen_US
dc.titleDevelopment and validation of an oligonucleotide ligation assay to detect lamivudine resistance in hepatitis B virusen_US
dc.typeJournalen_US
article.title.sourcetitleJournal of Virological Methodsen_US
article.volume233en_US
article.stream.affiliationsChildren's Hospital and Regional Medical Centeren_US
article.stream.affiliationsInstitute of research for development, Thailanden_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsHarvard School of Public Healthen_US
article.stream.affiliationsUniversity of Washington, Seattleen_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.