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Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/54563
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dc.contributor.authorTorsak Bunupuradahen_US
dc.contributor.authorKazuhiro Matsuokaen_US
dc.contributor.authorMayumi Imahashien_US
dc.contributor.authorYasumasa Iwatanien_US
dc.contributor.authorJintanat Ananworanichen_US
dc.contributor.authorThanyawee Puthanakiten_US
dc.contributor.authorVonthanak Saphonnen_US
dc.contributor.authorLinda Aurpibulen_US
dc.contributor.authorJiratchaya Sophonphanen_US
dc.contributor.authorTetsuya Yagien_US
dc.contributor.authorPraphan Phanuphaken_US
dc.contributor.authorWataru Sugiuraen_US
dc.date.accessioned2018-09-04T10:16:36Z-
dc.date.available2018-09-04T10:16:36Z-
dc.date.issued2015-12-01en_US
dc.identifier.issn17460808en_US
dc.identifier.issn17460794en_US
dc.identifier.other2-s2.0-84949944448en_US
dc.identifier.other10.2217/fvl.15.101en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84949944448&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/54563-
dc.description.abstract© 2015 Future Medicine Ltd. Aim: To evaluate the effect of APOBEC3G host factor on HIV/AIDS progression in perinatally HIV-infected Thai and Cambodian children with distinct clinical patterns; rapid progressors (RPs) and long-term nonprogressors (LTNPs). Materials & methods: APOBEC3G genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism in DNA samples. APOBEC3G-mediated G-to-A hypermutations were analyzed by sequencing of the vif/vpu genes from proviral DNA. Results: Frequency of APOBEC3G 186H/R genotypes, AA:AG:GG, in the RPs was 100:0:0% and 83:17:0% (p = 0.3) in LTNPs. Hypermutation of the vif-coding region was observed in none of the RPs and 8.3% of LTNPs (p = 0.5). Hypermutations at the vpu genes were not detected in either groups' proviral DNA. Conclusion: We observed no significant association of APOBEC3G genotypes and hypermutation rates between children with different profiles of HIV/AIDS disease progression.en_US
dc.subjectImmunology and Microbiologyen_US
dc.titleAPOBEC3G genotypes and proviral DNA hypermutations on HIV/AIDS disease progression in Thai and Cambodian childrenen_US
dc.typeJournalen_US
article.title.sourcetitleFuture Virologyen_US
article.volume10en_US
article.stream.affiliationsThe HIV Netherlands Australia Thailand Research Collaborationen_US
article.stream.affiliationsNational Hospital Organization, Japanen_US
article.stream.affiliationsNagoya Universityen_US
article.stream.affiliationsHJFen_US
article.stream.affiliationsSEARCHen_US
article.stream.affiliationsChulalongkorn Universityen_US
article.stream.affiliationsSocial Health Clinicen_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsGlaxoSmithKline K.K.en_US
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