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dc.contributor.authorAtchara Jaideeen_US
dc.contributor.authorThanika Promchaien_US
dc.contributor.authorKongkiat Trisuwanen_US
dc.contributor.authorSurat Laphookhieoen_US
dc.contributor.authorRoonglawan Rattanajaken_US
dc.contributor.authorSumalee Kamchonwongpaisanen_US
dc.contributor.authorStephen G. Pyneen_US
dc.contributor.authorThunwadee Ritthiwigromen_US
dc.description.abstractOne new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds were evaluated. Compound 1 showed significant in vitro antiplasmodial activity against the P. falciparum strains TM4 and K1 (multidrug resistant strain) with IC50values of 2.46±0.12 and 1.38±0.99 μg/mL, respectively with no cytotoxicity. Compound 9 had more modest antiplasmodial activity, but significant cytotoxicity.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleCytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalumen_US
article.title.sourcetitleNatural Product Communicationsen_US
article.volume10en_US Mai Universityen_US Fah Luang Universityen_US National Center for Genetic Engineering and Biotechnologyen_US of Wollongongen_US
Appears in Collections:CMUL: Journal Articles

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