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dc.contributor.authorStephen J. Kerren_US
dc.contributor.authorThanyawee Puthanakiten_US
dc.contributor.authorUng Vibolen_US
dc.contributor.authorLinda Aurpibulen_US
dc.contributor.authorSophan Vonthanaken_US
dc.contributor.authorPope Kosalaraksaen_US
dc.contributor.authorSuparat Kanjanavaniten_US
dc.contributor.authorRawiwan Hansudewechakulen_US
dc.contributor.authorJurai Wongsawaten_US
dc.contributor.authorWicharn Luesomboonen_US
dc.contributor.authorKattiya Ratanadiloken_US
dc.contributor.authorWasana Prasitsuebsaien_US
dc.contributor.authorKanchana Pruksakaewen_US
dc.contributor.authorJasper Van Der Lugten_US
dc.contributor.authorRobert Paulen_US
dc.contributor.authorJintanat Ananworanichen_US
dc.contributor.authorVictor Valcouren_US
dc.description.abstractHuman immunodeficiency virus (HIV)-negative children born to HIV-infected mothers may exhibit differences in neurodevelopment (ND) compared to age-and gender-matched controls whose lives have not been affected by HIV. This could occur due to exposure to HIV and antiretroviral agents in utero and perinatally, or differences in the environment in which they grow up. This study assessed neurodevelopmental outcomes in HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) children enrolled as controls in a multicenter ND study from Thailand and Cambodia. One hundred sixty HEU and 167 HUU children completed a neurodevelopmental assessment using the Beery Visual Motor Integration (VMI) test, Color Trails, Perdue Pegboard, and Child Behavior Checklist (CBCL). Thai children (n = 202) also completed the Wechsler Intelligence Scale (IQ) and Stanford-Binet II memory tests. In analyses adjusted for caregiver education, parent as caregiver, household income, age, and ethnicity, statistically significant lower scores were seen on verbal IQ (VIQ), full-scale IQ (FSIQ), and Binet Bead Memory among HEU compared to HUU. The mean (95% CI) differences were-6.13 (-10.3 to-1.96), p = 0.004;-4.57 (-8.80 to-0.35), p = 0.03; and-3.72 (-6.57 to-0.88), p = 0.01 for VIQ, FSIQ, and Binet Bead Memory, respectively. We observed no significant differences in performance IQ, other Binet memory domains, Color Trail, Perdue Pegboard, Beery VMI, or CBCL test scores. We conclude that HEU children evidence reductions in some neurodevelopmental outcomes compared to HUU; however, these differences are small and it remains unclear to what extent they have immediate and long-term clinical significance. © 2014 Taylor and Francis.en_US
dc.subjectSocial Sciencesen_US
dc.titleNeurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIVen_US
article.title.sourcetitleAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIVen_US
article.volume26en_US of New South Wales (UNSW) Australiaen_US Universityen_US Pediatric Hospitalen_US Mai Universityen_US Center for HIV/AIDS Dermatology and STDsen_US Kaen Universityen_US Hospitalen_US Prachanukroh Hospitalen_US Infectious Diseases Instituteen_US Savang Vadhana Memorial Hospitalen_US of Justiceen_US Institute of Global Health and Developmenten_US of Missouri-St. Louisen_US of California, San Franciscoen_US
Appears in Collections:CMUL: Journal Articles

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