Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/53248
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dc.contributor.authorS. Sangboonruangen_US
dc.contributor.authorP. Thammasiten_US
dc.contributor.authorN. Intasaien_US
dc.contributor.authorW. Kasinrerken_US
dc.contributor.authorC. Tayapiwatanaen_US
dc.contributor.authorK. Tragoolpuaen_US
dc.date.accessioned2018-09-04T09:45:51Z-
dc.date.available2018-09-04T09:45:51Z-
dc.date.issued2014-01-01en_US
dc.identifier.issn14765500en_US
dc.identifier.issn09291903en_US
dc.identifier.other2-s2.0-84903593918en_US
dc.identifier.other10.1038/cgt.2014.24en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84903593918&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/53248-
dc.description.abstractExtracellular matrix metalloproteinase inducer (EMMPRIN) exhibits overexpression in various cancers and promotes cancer progression and metastasis via the interaction with its associated molecules. The scFv-M6-1B9 intrabody has a potential ability to reduce EMMPRIN cell surface expression. However, the subsequent effect of scFv-M6-1B9 intrabody-mediated EMMPRIN abatement on its related molecules, α3β1-integrin, MCT1, MMP-2 and MMP-9, is undefined. Our results demonstrated that the scFv-M6-1B9 intrabody efficiently decreased α3β1-integrin cell surface expression levels. In addition, intracellular accumulation of MCT1 and lactate were increased. These results lead to suppression of features characteristic for tumor progression, including cell migration, proliferation and invasion, in a colorectal cancer cell line (Caco-2) although there was no difference in MMP expression. Thus, EMMPRIN represents an attractive target molecule for the disruption of cancer proliferation and metastasis. An scFv-M6-1B9 intrabody-based approach could be relevant for cancer gene therapy. © 2014 Nature America, Inc. All rights reserved.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleEMMPRIN reduction via scFv-M6-1B9 intrabody affects α3β1- integrin and MCT1 functions and results in suppression of progressive phenotype in the colorectal cancer cell line Caco-2en_US
dc.typeJournalen_US
article.title.sourcetitleCancer Gene Therapyen_US
article.volume21en_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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