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dc.contributor.authorKomsak Pinthaen_US
dc.contributor.authorSupachai Yodkeereeen_US
dc.contributor.authorPornsirit Pitchakarnen_US
dc.contributor.authorPornngarm Limtrakulen_US
dc.description.abstractRed rice contains pharmacological substances including phenolics, oryzanol, tocotrienol and tocopherol. Recently, red rice extract has been employed as a source of antioxidants for inhibition of tumor growth. This study was carried out to evaluate the anti-invasion effects of red rice extract fractions on cancer cells. It was found that at 100 μg/ml of crude ethanolic extract (CEE), hexane fraction (Hex) and dichloromethane fraction (DCM) could reduce HT1080 and MDA-MB-231 cancer cell invasion. Hex and DCM revealed higher potency levels than CEE, whereas an ethyl acetate fraction (EtOAc) had no effect. Gelatin zymography revealed that Hex decreased the secretion and activity of matrix metalloproteinase-2 and -9 (MMP-2 and-9). In contrast, the DCM fraction exhibited slightly effect on MMPs secretion and had no effect on MMPs activity. Collagenase activity was significantly inhibited by the Hex and DCM fractions. High amounts of γ-oryzanol and γ-tocotrienol were found in the Hex and DCM fractions and demonstrated an anti-invasion property. On the other hand, proanthocyanidin was detected only in the CEE fraction and reduced MDA-MB-231 cells invasion property. These observations suggest that proanthocyanidin, γ-oryzanol and γ-tocotrienol in the red rice fractions might be responsible for the anti invasion activity. The red rice extract may have a potential to serve as a food-derived chemotherapeutic agent for cancer patients.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleAnti-invasive activity against cancer cells of phytochemicals in red jasmine rice (Oryza sativa L.)en_US
article.title.sourcetitleAsian Pacific Journal of Cancer Preventionen_US
article.volume15en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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