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dc.contributor.authorDumnoensun Pruksakornen_US
dc.contributor.authorPremchai Tirankguraen_US
dc.contributor.authorSirichai Luevitoonvechkijen_US
dc.contributor.authorSamatchai Chamnongkichen_US
dc.contributor.authorNantawit Sugandhavesaen_US
dc.contributor.authorTaninnit Leerapunen_US
dc.contributor.authorPeraphan Pothacharoenen_US
dc.description.abstractIntroduction To prevent long-term unfavourable consequences to the articular cartilage of weight-bearing joints, serum biomarkers can be used to identify optimum loading of activities. This study aimed to investigate the circulation pattern of serum cartilage biomarkers in healthy adults in response to an uphill walk. Methods This study recruited 58 healthy participants for the experimental group and 24 matched participants for the control group. Participants in the experimental group walked continuously for 14 km on a pathway with a 5.97° incline, while participants from the control group walked on a horizontal pathway. Serum was collected from both groups preactivity (i.e. T1), immediately after activity (i.e. T2) and 24 hours after T1 (i.e. T3). The serum cartilage oligomeric matrix protein (COMP), chondroitin sulfate-WF6 (WF6) and hyaluronic acid (HA) levels at each time point were quantified using enzyme-linked immunosorbent assays, and the results analysed. Results Both groups shared similar demographic characteristics and activity duration. At T2, the serum COMP level of the experimental group was significantly higher than that of the control group, but the serum HA level of the experimental group was significantly lower than that of the control group. No significant difference between the serum WF6 levels of the experimental and control groups was observed at T2. Conclusion Increasing levels of serum COMP demonstrate articular cartilage susceptibility to the increasing load. An unsustainable, high serum COMP level and an undetectable change in WF6 level were considered to be a reversible physiological change of the car tilage. A change in ser um HA level could be related to intensive physical activity and dynamic clearance rather than a change in cartilage structure.en_US
dc.titleChanges in the serum cartilage biomarker levels of healthy adults in response to an uphill walken_US
article.title.sourcetitleSingapore Medical Journalen_US
article.volume54en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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