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dc.contributor.authorAtcharaporn Ontawongen_US
dc.contributor.authorNaruwan Saowakonen_US
dc.contributor.authorPornpun Vivithanapornen_US
dc.contributor.authorAnchalee Pongchaidechaen_US
dc.contributor.authorNarissara Lailerden_US
dc.contributor.authorDoungporn Amornlerdpisonen_US
dc.contributor.authorAnusorn Lungkaphinen_US
dc.contributor.authorChutima Srimaroengen_US
dc.date.accessioned2018-09-04T09:22:29Z-
dc.date.available2018-09-04T09:22:29Z-
dc.date.issued2013-07-01en_US
dc.identifier.issn23146141en_US
dc.identifier.issn23146133en_US
dc.identifier.other2-s2.0-84879348847en_US
dc.identifier.other10.1155/2013/820786en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84879348847&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/52232-
dc.description.abstractSpirogyra neglecta extract (SNE) has shown antihyperglycemia and antihyperlipidemia in type 2 diabetic mellitus (T2DM) rats. This study investigated the antioxidant and renoprotective effects of SNE in T2DM rats induced by high-fat diet with low-single dose streptozotocin. T2DM rats were fed daily with SNE (0.25, 0.5, and 1 g/kg BW) for 12 weeks. Renal morphology, malondialdehyde levels, qPCR, and western blotting were analyzed. Renal cortical slices were used to determine renal transport of organic anions, which are estrone sulfate and para-aminohippurate, mediated through organic anion transporter 3-Oat3. Insulin and PKC ζ were known to activate Oat3 function while it was inhibited by PKC α. Compared to T2DM, plasma glucose, triglyceride, insulin resistance, renal morphology, and malondialdehyde levels were significantly improved by SNE supplementation. Reduced glutathione peroxidase and nuclear factor B expressions were related to antioxidant effect of SNE. Oat3 mRNA and protein were not different among groups, but insulin-stimulated rOat3 followed by anion uptakes was abolished in T2DM. This was restored in the slices from SNE treatment. The mechanism of SNE-improved Oat3 was associated with PKC α and PKC ζ expressions and activities. These findings indicate that SNE has beneficial effects on renal transport through antioxidant enzymes and PKCs in T2DM rats. © 2013 Atcharaporn Ontawong et al.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleAntioxidant and renoprotective effects of Spirogyra neglecta (Hassall) Kützing extract in experimental type 2 diabetic ratsen_US
dc.typeJournalen_US
article.title.sourcetitleBioMed Research Internationalen_US
article.volume2013en_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsUniversity of Phayaoen_US
article.stream.affiliationsSuranaree University of Technologyen_US
article.stream.affiliationsMahidol Universityen_US
article.stream.affiliationsMaejo Universityen_US
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