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dc.contributor.authorKwankamol Sastrarujien_US
dc.contributor.authorThanapat Sastrarujien_US
dc.contributor.authorAlison T. Ungen_US
dc.contributor.authorRenate Griffithen_US
dc.contributor.authorAraya Jatisatienren_US
dc.contributor.authorStephen G. Pyneen_US
dc.description.abstractThirty-two new stemofoline analogues were prepared from didehydrostemofoline for studies as AChE inhibitors. C-3 Side-chain modified amino, carbamate, triazole and oxazole stemofoline derivatives were prepared. In general the amine derivatives were found to be stronger inhibitors of AChE than their alcohol analogues that we previously reported. Compounds 5 and 26, with small C-3 side-chain substituents, were two of the most active inhibitors. Preliminary molecular docking studies suggested that these compounds may inhibit AChE by binding horizontally along the passage of the active-site gorge and block access to acetylcholine. © 2012 Elsevier Ltd. All rights reserved.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleSynthesis of stemofoline analogues as acetylcholinesterase inhibitorsen_US
article.volume68en_US of Wollongongen_US of Technology Sydneyen_US of New South Wales (UNSW) Australiaen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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