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dc.contributor.authorW. Paengsrien_US
dc.contributor.authorV. S. Leeen_US
dc.contributor.authorW. L. Chongen_US
dc.contributor.authorH. A. Wahaben_US
dc.contributor.authorA. Barameeen_US
dc.description.abstractA series of new substituted derivatives of 2-hydroxy-l, 4-naphthoquinone were successfully prepared by a Mannich reaction and evaluated for their in vitro anti-tuberculosis activity against Mycobacterium tuberculosis H37Ra. All the compounds were tested by Green Fluorescent Protein Microplate Assay (GFPMA) where rifampicin, streptomycin, isoniazid and ofloxacin were used as a reference drug. Two compounds, 2-hydroxy-3-((pyridin-2-ylamino)methyl)naphthalene-1,4-dione and 2-hydroxy-3-((2-hydroxyphenyl)(pyridin-2-ylamino)methyl) naphthalene-1,4-dione, exhibited a significant activity against tuberculosis. Three dimension structure of the most active compound, 2a with the enoyl ACP reductase from molecular docking in comparison with the crystallized inhibitor complex suggesting the potential use of novel substituted derivatives of 2-hydroxy-l,4-naphthoquinone as promising antituberculosis inhibitors. © 2012 Academic Journals Inc.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleSynthesis, antituberculosis activity and molecular docking studies for novel naphthoquinone derivativesen_US
article.title.sourcetitleInternational Journal of Biological Chemistryen_US
article.volume6en_US Mai Universityen_US of Malayaen_US Universityen_US Sains Malayaen_US
Appears in Collections:CMUL: Journal Articles

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